Comparison of rigid and deformable image registration for nasopharyngeal carcinoma radiotherapy planning with diagnostic position PET/CT

Yudai Kai, Hidetaka Arimura, Ryo Toya, Tetsuo Saito, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Shinya Shiraishi, Yoshinobu Shimohigashi, Masato Maruyama, Natsuo Oya

Research output: Contribution to journalArticle

Abstract

Purpose: This observer study aimed to compare rigid image registration (RIR) with deformable image registration (DIR) for diagnostic position (DP) positron emission tomography/computed tomography (PET/CT) images in the delineation of gross tumor volumes (GTVs) in nasopharyngeal carcinoma (NPC) radiotherapy planning. Materials and methods: Four radiation oncologists individually delineated the GTVs, GTVRIR, and GTVDIR, on planning CT (pCT) images registered with DP-PET/CT images using RIR and B-spline-based DIR, respectively. Reference GTVs were independently delineated by all radiation oncologists using radiotherapy position (RP)-PET/CT images. DP- and RP-PET/CT images for 14 patients with NPC were acquired using early and delayed scans, respectively. Dice’s similarity coefficient (DSC), mean distance to agreement, and volume agreement with reference GTVs were compared by considering the interobserver variability in reference contours. Results: The average DSCs for GTVRIR and GTVDIR were 0.77 and 0.77, which were acceptable for GTV delineation. There were no statistically significant differences between GTVRIR and GTVDIR in all evaluation indexes (p > 0.05). Furthermore, the correlation between neck flexion angle differences and GTV accuracy was not statistically significant (p > 0.05). Conclusion: RIR was a feasible choice compared with the B-spline-based DIR in GTV delineation for NPC under variations of neck flexion angle.

Original languageEnglish
JournalJapanese Journal of Radiology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Tumor Burden
Radiotherapy
Neck
Observer Variation
Positron Emission Tomography Computed Tomography
Nasopharyngeal carcinoma

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Comparison of rigid and deformable image registration for nasopharyngeal carcinoma radiotherapy planning with diagnostic position PET/CT. / Kai, Yudai; Arimura, Hidetaka; Toya, Ryo; Saito, Tetsuo; Matsuyama, Tomohiko; Fukugawa, Yoshiyuki; Shiraishi, Shinya; Shimohigashi, Yoshinobu; Maruyama, Masato; Oya, Natsuo.

In: Japanese Journal of Radiology, 01.01.2019.

Research output: Contribution to journalArticle

Kai, Yudai ; Arimura, Hidetaka ; Toya, Ryo ; Saito, Tetsuo ; Matsuyama, Tomohiko ; Fukugawa, Yoshiyuki ; Shiraishi, Shinya ; Shimohigashi, Yoshinobu ; Maruyama, Masato ; Oya, Natsuo. / Comparison of rigid and deformable image registration for nasopharyngeal carcinoma radiotherapy planning with diagnostic position PET/CT. In: Japanese Journal of Radiology. 2019.
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abstract = "Purpose: This observer study aimed to compare rigid image registration (RIR) with deformable image registration (DIR) for diagnostic position (DP) positron emission tomography/computed tomography (PET/CT) images in the delineation of gross tumor volumes (GTVs) in nasopharyngeal carcinoma (NPC) radiotherapy planning. Materials and methods: Four radiation oncologists individually delineated the GTVs, GTVRIR, and GTVDIR, on planning CT (pCT) images registered with DP-PET/CT images using RIR and B-spline-based DIR, respectively. Reference GTVs were independently delineated by all radiation oncologists using radiotherapy position (RP)-PET/CT images. DP- and RP-PET/CT images for 14 patients with NPC were acquired using early and delayed scans, respectively. Dice’s similarity coefficient (DSC), mean distance to agreement, and volume agreement with reference GTVs were compared by considering the interobserver variability in reference contours. Results: The average DSCs for GTVRIR and GTVDIR were 0.77 and 0.77, which were acceptable for GTV delineation. There were no statistically significant differences between GTVRIR and GTVDIR in all evaluation indexes (p > 0.05). Furthermore, the correlation between neck flexion angle differences and GTV accuracy was not statistically significant (p > 0.05). Conclusion: RIR was a feasible choice compared with the B-spline-based DIR in GTV delineation for NPC under variations of neck flexion angle.",
author = "Yudai Kai and Hidetaka Arimura and Ryo Toya and Tetsuo Saito and Tomohiko Matsuyama and Yoshiyuki Fukugawa and Shinya Shiraishi and Yoshinobu Shimohigashi and Masato Maruyama and Natsuo Oya",
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AU - Saito, Tetsuo

AU - Matsuyama, Tomohiko

AU - Fukugawa, Yoshiyuki

AU - Shiraishi, Shinya

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