Comparison of test-injection method and fixed-time method for depiction of hepatocellular carcinoma using dynamic steady-state free precession magnetic resonance imaging

Kenji Shinozaki, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Tsuyoshi Tajima, Akihiro Nishie, Tomohiro Nakayama, Daisuke Kakihara, Mitsuo Shimada, Hiroshi Honda

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Abstract

Objective: The purpose of this study was to clarify the usefulness of the test-injection method as compared with the fixed-time method in dynamic magnetic resonance (MR) imaging of hepatocellular carcinoma (HCC). Methods: Ninety-seven patients with a total of 118 hepatocellular carcinomas underwent 3-dimensional fast imaging with steady-state free precession (3D-FISP) for dynamic study of the liver as well as catheter-assisted computed tomography hepatic angiography (CTHA) for preoperative evaluation. In 42 cases, the fixed-time method (30-second scan time delay in the hepatic arterial phase [HAP]) was performed (group 1), and in 55 cases, the test-injection method was performed (group 2). The following parameters were evaluated: 1) the adequacy of the HAP, 2) tumor vascularity using CTHA findings as a gold standard, and 3) the contrast-to-noise ratio (CNR) of the HCC during the HAP of dynamic MR imaging. Results: In group 1, 79% (33 of 42) of the cases were obtained at the optimal HAP; the percentage in group 2 was 98% (54 of 55) of the cases. This difference was statistically significant (P < 0.05). The vascularity of 82% of the tumors in group 1 and 89% of those in group 2 was diagnosed correctly. Regarding hypervascular tumors, correct evaluation of tumor vascularity was made in 87% of group 1 cases and 95% of group 2 cases. No significant difference was present between the 2 groups (total: P = 0.43, hypervascular HCC: P = 0.29). 3) The CNR calculated for all HCCs in group 2 (mean ± SD: 8.66 ± 11.0) was significantly higher than that for HCCs in group 1 (4.29 ± 9.44; P < 0.05). As for the hypervascular tumors, the CNR calculated for group 2 (mean ± SD: 9.89 ± 10.6) was also significantly higher than that for group 1 (5.52 ± 9.81; P < 0.05). Conclusion: The 3D-FISP dynamic MR imaging using the test-injection method resulted in better demonstration of HCC than the 3D-FISP using the fixed-time method.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume28
Issue number5
DOIs
Publication statusPublished - Sep 1 2004

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Hepatocellular Carcinoma
Magnetic Resonance Imaging
Injections
Liver
Noise
Neoplasms
Catheters

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Comparison of test-injection method and fixed-time method for depiction of hepatocellular carcinoma using dynamic steady-state free precession magnetic resonance imaging. / Shinozaki, Kenji; Yoshimitsu, Kengo; Irie, Hiroyuki; Aibe, Hitoshi; Tajima, Tsuyoshi; Nishie, Akihiro; Nakayama, Tomohiro; Kakihara, Daisuke; Shimada, Mitsuo; Honda, Hiroshi.

In: Journal of Computer Assisted Tomography, Vol. 28, No. 5, 01.09.2004, p. 628-634.

Research output: Contribution to journalArticle

Shinozaki, Kenji ; Yoshimitsu, Kengo ; Irie, Hiroyuki ; Aibe, Hitoshi ; Tajima, Tsuyoshi ; Nishie, Akihiro ; Nakayama, Tomohiro ; Kakihara, Daisuke ; Shimada, Mitsuo ; Honda, Hiroshi. / Comparison of test-injection method and fixed-time method for depiction of hepatocellular carcinoma using dynamic steady-state free precession magnetic resonance imaging. In: Journal of Computer Assisted Tomography. 2004 ; Vol. 28, No. 5. pp. 628-634.
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T1 - Comparison of test-injection method and fixed-time method for depiction of hepatocellular carcinoma using dynamic steady-state free precession magnetic resonance imaging

AU - Shinozaki, Kenji

AU - Yoshimitsu, Kengo

AU - Irie, Hiroyuki

AU - Aibe, Hitoshi

AU - Tajima, Tsuyoshi

AU - Nishie, Akihiro

AU - Nakayama, Tomohiro

AU - Kakihara, Daisuke

AU - Shimada, Mitsuo

AU - Honda, Hiroshi

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Objective: The purpose of this study was to clarify the usefulness of the test-injection method as compared with the fixed-time method in dynamic magnetic resonance (MR) imaging of hepatocellular carcinoma (HCC). Methods: Ninety-seven patients with a total of 118 hepatocellular carcinomas underwent 3-dimensional fast imaging with steady-state free precession (3D-FISP) for dynamic study of the liver as well as catheter-assisted computed tomography hepatic angiography (CTHA) for preoperative evaluation. In 42 cases, the fixed-time method (30-second scan time delay in the hepatic arterial phase [HAP]) was performed (group 1), and in 55 cases, the test-injection method was performed (group 2). The following parameters were evaluated: 1) the adequacy of the HAP, 2) tumor vascularity using CTHA findings as a gold standard, and 3) the contrast-to-noise ratio (CNR) of the HCC during the HAP of dynamic MR imaging. Results: In group 1, 79% (33 of 42) of the cases were obtained at the optimal HAP; the percentage in group 2 was 98% (54 of 55) of the cases. This difference was statistically significant (P < 0.05). The vascularity of 82% of the tumors in group 1 and 89% of those in group 2 was diagnosed correctly. Regarding hypervascular tumors, correct evaluation of tumor vascularity was made in 87% of group 1 cases and 95% of group 2 cases. No significant difference was present between the 2 groups (total: P = 0.43, hypervascular HCC: P = 0.29). 3) The CNR calculated for all HCCs in group 2 (mean ± SD: 8.66 ± 11.0) was significantly higher than that for HCCs in group 1 (4.29 ± 9.44; P < 0.05). As for the hypervascular tumors, the CNR calculated for group 2 (mean ± SD: 9.89 ± 10.6) was also significantly higher than that for group 1 (5.52 ± 9.81; P < 0.05). Conclusion: The 3D-FISP dynamic MR imaging using the test-injection method resulted in better demonstration of HCC than the 3D-FISP using the fixed-time method.

AB - Objective: The purpose of this study was to clarify the usefulness of the test-injection method as compared with the fixed-time method in dynamic magnetic resonance (MR) imaging of hepatocellular carcinoma (HCC). Methods: Ninety-seven patients with a total of 118 hepatocellular carcinomas underwent 3-dimensional fast imaging with steady-state free precession (3D-FISP) for dynamic study of the liver as well as catheter-assisted computed tomography hepatic angiography (CTHA) for preoperative evaluation. In 42 cases, the fixed-time method (30-second scan time delay in the hepatic arterial phase [HAP]) was performed (group 1), and in 55 cases, the test-injection method was performed (group 2). The following parameters were evaluated: 1) the adequacy of the HAP, 2) tumor vascularity using CTHA findings as a gold standard, and 3) the contrast-to-noise ratio (CNR) of the HCC during the HAP of dynamic MR imaging. Results: In group 1, 79% (33 of 42) of the cases were obtained at the optimal HAP; the percentage in group 2 was 98% (54 of 55) of the cases. This difference was statistically significant (P < 0.05). The vascularity of 82% of the tumors in group 1 and 89% of those in group 2 was diagnosed correctly. Regarding hypervascular tumors, correct evaluation of tumor vascularity was made in 87% of group 1 cases and 95% of group 2 cases. No significant difference was present between the 2 groups (total: P = 0.43, hypervascular HCC: P = 0.29). 3) The CNR calculated for all HCCs in group 2 (mean ± SD: 8.66 ± 11.0) was significantly higher than that for HCCs in group 1 (4.29 ± 9.44; P < 0.05). As for the hypervascular tumors, the CNR calculated for group 2 (mean ± SD: 9.89 ± 10.6) was also significantly higher than that for group 1 (5.52 ± 9.81; P < 0.05). Conclusion: The 3D-FISP dynamic MR imaging using the test-injection method resulted in better demonstration of HCC than the 3D-FISP using the fixed-time method.

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