Comparison of the Esophageal Manometric Characteristics of Idiopathic and Reflux-Associated Esophageal Spasm: Evaluation by 24-Hour Ambulatory Esophageal Motility and pH Monitoring

Haruo Hayashi, Kazunori Mine, Masako Hosoi, Osamu Tsuchida, Masanori Handa, Naoko Kinukawa, Katsumi Andou, Chiharu Kubo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Diffuse esophageal spasm (DES) is a typical esophageal dysfunction, but its cause is unknown. DES has been classified into reflux-associated esophageal spasm (RDES), caused by acid exposure, and idiopathic esophageal spasm (IDES), of unknown causes. The differences in esophageal motility pattern between the RDES and IDES are clues to elucidating the pathogenesis of DES. Although 24-hr ambulatory esophageal motility and pH monitoring is considered a feasible method for evaluating gastroesophageal reflux and esophageal function, most researchers previously defined the RDES as DES accompanied by esophagitis and heartburn using standard manometry over a short time frame. To clarify the pathogenesis of RDES, we did this research using 24-hr ambulatory esophageal motility and pH monitoring. The investigation included 25 normal controls and 116 patients with upper digestive symptoms. Among the 116 patients, 45 had DES (11 RDES, 30 IDES, and DES-GERD coexistence). Patients with RDES showed a significantly higher frequency of simultaneous contractions than did patients with IDES. Heartburn has been said to be peculiar to RDES, but also occurred in 12.5% of IDES. No significant differences in the mean pH of the esophagus during acid reflux were found between the RDES and IDES patients. Based on the results, we have proposed a refined definition of RDES.

Original languageEnglish
Pages (from-to)2124-2131
Number of pages8
JournalDigestive Diseases and Sciences
Volume48
Issue number11
DOIs
Publication statusPublished - Nov 1 2003

Fingerprint

Diffuse Esophageal Spasm
Esophageal pH Monitoring
Heartburn
Gastroesophageal Reflux

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Comparison of the Esophageal Manometric Characteristics of Idiopathic and Reflux-Associated Esophageal Spasm : Evaluation by 24-Hour Ambulatory Esophageal Motility and pH Monitoring. / Hayashi, Haruo; Mine, Kazunori; Hosoi, Masako; Tsuchida, Osamu; Handa, Masanori; Kinukawa, Naoko; Andou, Katsumi; Kubo, Chiharu.

In: Digestive Diseases and Sciences, Vol. 48, No. 11, 01.11.2003, p. 2124-2131.

Research output: Contribution to journalArticle

@article{f255da5df3ef4fd58ce35f1870a96913,
title = "Comparison of the Esophageal Manometric Characteristics of Idiopathic and Reflux-Associated Esophageal Spasm: Evaluation by 24-Hour Ambulatory Esophageal Motility and pH Monitoring",
abstract = "Diffuse esophageal spasm (DES) is a typical esophageal dysfunction, but its cause is unknown. DES has been classified into reflux-associated esophageal spasm (RDES), caused by acid exposure, and idiopathic esophageal spasm (IDES), of unknown causes. The differences in esophageal motility pattern between the RDES and IDES are clues to elucidating the pathogenesis of DES. Although 24-hr ambulatory esophageal motility and pH monitoring is considered a feasible method for evaluating gastroesophageal reflux and esophageal function, most researchers previously defined the RDES as DES accompanied by esophagitis and heartburn using standard manometry over a short time frame. To clarify the pathogenesis of RDES, we did this research using 24-hr ambulatory esophageal motility and pH monitoring. The investigation included 25 normal controls and 116 patients with upper digestive symptoms. Among the 116 patients, 45 had DES (11 RDES, 30 IDES, and DES-GERD coexistence). Patients with RDES showed a significantly higher frequency of simultaneous contractions than did patients with IDES. Heartburn has been said to be peculiar to RDES, but also occurred in 12.5{\%} of IDES. No significant differences in the mean pH of the esophagus during acid reflux were found between the RDES and IDES patients. Based on the results, we have proposed a refined definition of RDES.",
author = "Haruo Hayashi and Kazunori Mine and Masako Hosoi and Osamu Tsuchida and Masanori Handa and Naoko Kinukawa and Katsumi Andou and Chiharu Kubo",
year = "2003",
month = "11",
day = "1",
doi = "10.1023/B:DDAS.0000004514.91064.7f",
language = "English",
volume = "48",
pages = "2124--2131",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "11",

}

TY - JOUR

T1 - Comparison of the Esophageal Manometric Characteristics of Idiopathic and Reflux-Associated Esophageal Spasm

T2 - Evaluation by 24-Hour Ambulatory Esophageal Motility and pH Monitoring

AU - Hayashi, Haruo

AU - Mine, Kazunori

AU - Hosoi, Masako

AU - Tsuchida, Osamu

AU - Handa, Masanori

AU - Kinukawa, Naoko

AU - Andou, Katsumi

AU - Kubo, Chiharu

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Diffuse esophageal spasm (DES) is a typical esophageal dysfunction, but its cause is unknown. DES has been classified into reflux-associated esophageal spasm (RDES), caused by acid exposure, and idiopathic esophageal spasm (IDES), of unknown causes. The differences in esophageal motility pattern between the RDES and IDES are clues to elucidating the pathogenesis of DES. Although 24-hr ambulatory esophageal motility and pH monitoring is considered a feasible method for evaluating gastroesophageal reflux and esophageal function, most researchers previously defined the RDES as DES accompanied by esophagitis and heartburn using standard manometry over a short time frame. To clarify the pathogenesis of RDES, we did this research using 24-hr ambulatory esophageal motility and pH monitoring. The investigation included 25 normal controls and 116 patients with upper digestive symptoms. Among the 116 patients, 45 had DES (11 RDES, 30 IDES, and DES-GERD coexistence). Patients with RDES showed a significantly higher frequency of simultaneous contractions than did patients with IDES. Heartburn has been said to be peculiar to RDES, but also occurred in 12.5% of IDES. No significant differences in the mean pH of the esophagus during acid reflux were found between the RDES and IDES patients. Based on the results, we have proposed a refined definition of RDES.

AB - Diffuse esophageal spasm (DES) is a typical esophageal dysfunction, but its cause is unknown. DES has been classified into reflux-associated esophageal spasm (RDES), caused by acid exposure, and idiopathic esophageal spasm (IDES), of unknown causes. The differences in esophageal motility pattern between the RDES and IDES are clues to elucidating the pathogenesis of DES. Although 24-hr ambulatory esophageal motility and pH monitoring is considered a feasible method for evaluating gastroesophageal reflux and esophageal function, most researchers previously defined the RDES as DES accompanied by esophagitis and heartburn using standard manometry over a short time frame. To clarify the pathogenesis of RDES, we did this research using 24-hr ambulatory esophageal motility and pH monitoring. The investigation included 25 normal controls and 116 patients with upper digestive symptoms. Among the 116 patients, 45 had DES (11 RDES, 30 IDES, and DES-GERD coexistence). Patients with RDES showed a significantly higher frequency of simultaneous contractions than did patients with IDES. Heartburn has been said to be peculiar to RDES, but also occurred in 12.5% of IDES. No significant differences in the mean pH of the esophagus during acid reflux were found between the RDES and IDES patients. Based on the results, we have proposed a refined definition of RDES.

UR - http://www.scopus.com/inward/record.url?scp=0346156043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346156043&partnerID=8YFLogxK

U2 - 10.1023/B:DDAS.0000004514.91064.7f

DO - 10.1023/B:DDAS.0000004514.91064.7f

M3 - Article

C2 - 14705816

AN - SCOPUS:0346156043

VL - 48

SP - 2124

EP - 2131

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 11

ER -