Comparison of the healing process in plated and non-plated fractures of the mandible in rats

L. Rasubala, H. Yoshikawa, A. A S Islam, Kengo Nagata, T. Iijima, M. Ohishi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume42
Issue number4
DOIs
Publication statusPublished - Aug 1 2004

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Bone Morphogenetic Protein 2
Mandible
Periosteum
Morphogenesis
Wistar Rats
Antibodies
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Otorhinolaryngology
  • Surgery

Cite this

Comparison of the healing process in plated and non-plated fractures of the mandible in rats. / Rasubala, L.; Yoshikawa, H.; Islam, A. A S; Nagata, Kengo; Iijima, T.; Ohishi, M.

In: British Journal of Oral and Maxillofacial Surgery, Vol. 42, No. 4, 01.08.2004, p. 315-322.

Research output: Contribution to journalArticle

Rasubala, L. ; Yoshikawa, H. ; Islam, A. A S ; Nagata, Kengo ; Iijima, T. ; Ohishi, M. / Comparison of the healing process in plated and non-plated fractures of the mandible in rats. In: British Journal of Oral and Maxillofacial Surgery. 2004 ; Vol. 42, No. 4. pp. 315-322.
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