Comparison of the healing process in plated and non-plated fractures of the mandible in rats

L. Rasubala, H. Yoshikawa, A. A.S. Islam, K. Nagata, T. Iijima, M. Ohishi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume42
Issue number4
DOIs
Publication statusPublished - Aug 1 2004

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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