Comparison of the healing process in plated and non-plated fractures of the mandible in rats

L. Rasubala, H. Yoshikawa, A. A.S. Islam, K. Nagata, T. Iijima, M. Ohishi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume42
Issue number4
DOIs
Publication statusPublished - Aug 1 2004

Fingerprint

Bone Morphogenetic Protein 2
Mandible
Periosteum
Morphogenesis
Wistar Rats
Antibodies
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Comparison of the healing process in plated and non-plated fractures of the mandible in rats. / Rasubala, L.; Yoshikawa, H.; Islam, A. A.S.; Nagata, K.; Iijima, T.; Ohishi, M.

In: British Journal of Oral and Maxillofacial Surgery, Vol. 42, No. 4, 01.08.2004, p. 315-322.

Research output: Contribution to journalArticle

Rasubala, L. ; Yoshikawa, H. ; Islam, A. A.S. ; Nagata, K. ; Iijima, T. ; Ohishi, M. / Comparison of the healing process in plated and non-plated fractures of the mandible in rats. In: British Journal of Oral and Maxillofacial Surgery. 2004 ; Vol. 42, No. 4. pp. 315-322.
@article{337c381750b74ca29983340e4f6a90b3,
title = "Comparison of the healing process in plated and non-plated fractures of the mandible in rats",
abstract = "We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.",
author = "L. Rasubala and H. Yoshikawa and Islam, {A. A.S.} and K. Nagata and T. Iijima and M. Ohishi",
year = "2004",
month = "8",
day = "1",
doi = "10.1016/j.bjoms.2004.02.020",
language = "English",
volume = "42",
pages = "315--322",
journal = "British Journal of Oral and Maxillofacial Surgery",
issn = "0266-4356",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Comparison of the healing process in plated and non-plated fractures of the mandible in rats

AU - Rasubala, L.

AU - Yoshikawa, H.

AU - Islam, A. A.S.

AU - Nagata, K.

AU - Iijima, T.

AU - Ohishi, M.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

AB - We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n=36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.

UR - http://www.scopus.com/inward/record.url?scp=3042595330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042595330&partnerID=8YFLogxK

U2 - 10.1016/j.bjoms.2004.02.020

DO - 10.1016/j.bjoms.2004.02.020

M3 - Article

C2 - 15225949

AN - SCOPUS:3042595330

VL - 42

SP - 315

EP - 322

JO - British Journal of Oral and Maxillofacial Surgery

JF - British Journal of Oral and Maxillofacial Surgery

SN - 0266-4356

IS - 4

ER -