Abstract
Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.
Original language | English |
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Pages (from-to) | 959-964 |
Number of pages | 6 |
Journal | In Vivo |
Volume | 19 |
Issue number | 6 |
Publication status | Published - Nov 2005 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology