Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

Miki Tsujita-Kyutoku; Norihisa Uehara; Yoichiro Matsuoka; Shigeo Kyutoku; Yutaka Ogawa; Airo Tsubura

Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

Miki Tsujita-Kyutoku, Norihisa Uehara, Yoichiro Matsuoka, Shigeo Kyutoku, Yutaka Ogawa, Airo Tsubura

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.

Original language	English
Pages (from-to)	959-964
Number of pages	6
Journal	In Vivo
Volume	19
Issue number	6
Publication status	Published - Nov 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

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Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions. / Tsujita-Kyutoku, Miki; Uehara, Norihisa; Matsuoka, Yoichiro; Kyutoku, Shigeo; Ogawa, Yutaka; Tsubura, Airo.

In: In Vivo, Vol. 19, No. 6, 11.2005, p. 959-964.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.",

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T1 - Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

AU - Tsujita-Kyutoku, Miki

AU - Uehara, Norihisa

AU - Matsuoka, Yoichiro

AU - Kyutoku, Shigeo

AU - Ogawa, Yutaka

AU - Tsubura, Airo

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N2 - Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.

AB - Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.

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