Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

Miki Tsujita-Kyutoku, Norihisa Uehara, Yoichiro Matsuoka, Shigeo Kyutoku, Yutaka Ogawa, Airo Tsubura

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21 Citations (Scopus)


Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.

Original languageEnglish
Pages (from-to)959-964
Number of pages6
JournalIn Vivo
Issue number6
Publication statusPublished - Nov 1 2005
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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