Abstract
Background: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. Materials and methods: Fibroblasts were isolated from the central and penipheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. Results: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-β) receptor 1 and Smad 2/3. Conclusion: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-β/Smad pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 959-964 |
| Number of pages | 6 |
| Journal | In Vivo |
| Volume | 19 |
| Issue number | 6 |
| Publication status | Published - Nov 1 2005 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
Cite this
Tsujita-Kyutoku, M., Uehara, N., Matsuoka, Y., Kyutoku, S., Ogawa, Y., & Tsubura, A. (2005). Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions. In Vivo, 19(6), 959-964.