Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic

Toshihide Tsuda, Eiji Yamamoto, Akira Babazono, Yoshio Mino, Yoshiki Kishi, Norio Kurumatani, Takanori Ogawa, Hideyasu Aoyama

Research output: Contribution to journalArticle

Abstract

Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up); or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalApplied Organometallic Chemistry
Volume8
Issue number3
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Arsenic
Water

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Inorganic Chemistry

Cite this

Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic. / Tsuda, Toshihide; Yamamoto, Eiji; Babazono, Akira; Mino, Yoshio; Kishi, Yoshiki; Kurumatani, Norio; Ogawa, Takanori; Aoyama, Hideyasu.

In: Applied Organometallic Chemistry, Vol. 8, No. 3, 01.01.1994, p. 237-244.

Research output: Contribution to journalArticle

Tsuda, Toshihide ; Yamamoto, Eiji ; Babazono, Akira ; Mino, Yoshio ; Kishi, Yoshiki ; Kurumatani, Norio ; Ogawa, Takanori ; Aoyama, Hideyasu. / Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic. In: Applied Organometallic Chemistry. 1994 ; Vol. 8, No. 3. pp. 237-244.
@article{400121cb3c7a47e3b46bbda92bc0fdd7,
title = "Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic",
abstract = "Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up); or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred.",
author = "Toshihide Tsuda and Eiji Yamamoto and Akira Babazono and Yoshio Mino and Yoshiki Kishi and Norio Kurumatani and Takanori Ogawa and Hideyasu Aoyama",
year = "1994",
month = "1",
day = "1",
doi = "10.1002/aoc.590080313",
language = "English",
volume = "8",
pages = "237--244",
journal = "Applied Organometallic Chemistry",
issn = "0268-2605",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic

AU - Tsuda, Toshihide

AU - Yamamoto, Eiji

AU - Babazono, Akira

AU - Mino, Yoshio

AU - Kishi, Yoshiki

AU - Kurumatani, Norio

AU - Ogawa, Takanori

AU - Aoyama, Hideyasu

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up); or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred.

AB - Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up); or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred.

UR - http://www.scopus.com/inward/record.url?scp=84989571883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989571883&partnerID=8YFLogxK

U2 - 10.1002/aoc.590080313

DO - 10.1002/aoc.590080313

M3 - Article

AN - SCOPUS:84989571883

VL - 8

SP - 237

EP - 244

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

SN - 0268-2605

IS - 3

ER -