Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Takeshi Yamada, Hiroyuki Sasaki, Hirokazu Furuya, Takashi Miyata, Ikuo Goto, Yoshiyuki Sakaki

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume149
Issue number2
DOIs
Publication statusPublished - Dec 16 1987

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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