Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Takeshi Yamada; Hiroyuki Sasaki; Hirokazu Furuya; Takashi Miyata; Ikuo Goto; Yoshiyuki Sakaki

doi:10.1016/0006-291X(87)90419-0

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Takeshi Yamada, Hiroyuki Sasaki, Hirokazu Furuya, Takashi Miyata, Ikuo Goto, Yoshiyuki Sakaki

Department of Molecular and Structural Biology

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10^-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

Original language	English
Pages (from-to)	665-671
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	149
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(87)90419-0
Publication status	Published - Dec 16 1987

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0006-291X(87)90419-0

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abstract = "The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).",

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AU - Yamada, Takeshi

AU - Sasaki, Hiroyuki

AU - Furuya, Hirokazu

AU - Miyata, Takashi

AU - Goto, Ikuo

AU - Sakaki, Yoshiyuki

PY - 1987/12/16

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AB - The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1×10-9/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

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Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Abstract

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