Complete response of transverse colon carcinoma to S1, a new chemotherapy agent: Report of a case

Koshi Mimori, Masaki Mori, Hideo Baba, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A complete response to a new chemotherapeutic agent, S1, was achieved in a 64-year-old Japanese man with advanced transverse colon cancer. S1 is a combination of the agents tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid. Because the patient was considered to be a high operative risk due to his poor general condition, S1 was administered at 100 mg/day for 5 days/week over 12 weeks. However, as the serum carcinoembryonic antigen level continued to gradually increase, partial resection of the transverse colon was finally performed. Histopathological study of the resected specimen showed mucin pools in the colon wall with no residual viable cancer cells. No perioperative complications were recognized and the patient is now leading a normal life 6 months after his operation without any signs of recurrence.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
JournalSurgery today
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 1 1995

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Transverse Colon
Oxonic Acid
Tegafur
Carcinoma
Drug Therapy
Carcinoembryonic Antigen
Residual Neoplasm
Mucins
Colonic Neoplasms
Colon
Recurrence
Serum
gimeracil

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Complete response of transverse colon carcinoma to S1, a new chemotherapy agent : Report of a case. / Mimori, Koshi; Mori, Masaki; Baba, Hideo; Maehara, Yoshihiko; Sugimachi, Keizo.

In: Surgery today, Vol. 25, No. 8, 01.08.1995, p. 741-744.

Research output: Contribution to journalArticle

Mimori, Koshi ; Mori, Masaki ; Baba, Hideo ; Maehara, Yoshihiko ; Sugimachi, Keizo. / Complete response of transverse colon carcinoma to S1, a new chemotherapy agent : Report of a case. In: Surgery today. 1995 ; Vol. 25, No. 8. pp. 741-744.
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