Complete response to treatment with hepatic arterial chemoembolization and arterial infusion chemotherapy in a case of hepatocellular carcinoma with multiple lung metastases

Masatora Haruno, Kazufumi Dohmen, Minako Oyama, Keita Fukaura, Norihiko Kubo, Hirofumi Tanaka, Hideyuki Higashihara, Masatoshi Okazaki, Shinji Shimoda

Research output: Contribution to journalArticle

Abstract

A 68-year-old Japanese male admitted at our hospital because of further examination and therapy for liver tumors. Based on the elevated values of serum alpha-fetoprotein (AFP) and PIVKA II and imaging examinations, he was diagnosed to have primary hepatocellular carcinoma (HCC) with multiple lung metastases. After the therapy with 4 sessions of transcatheter arterial chemoembolization (TACE) and arterial infusion chemotherapy (TAI) for primary HCC measuring 8 cm in diameter, lung nodules were disappeared along with aprominent decrease to the normal levels of the values of serum AFP and PIVKA II. The clinical course revealed that a complete response was obtained. Although the precise mechanisms underlying this intriguing phenomenon remain unknown, thus possibilities are raised that natural regression of HCC or the necrotic change of tumor cells on the immunological effect produced by TACE/TAI.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalActa Hepatologica Japonica
Volume50
Issue number4
DOIs
Publication statusPublished - Jun 5 2009

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Hepatocellular Carcinoma
alpha-Fetoproteins
Neoplasm Metastasis
Drug Therapy
Lung
Liver
Serum
Neoplasms
Reference Values
Therapeutics
acarboxyprothrombin

All Science Journal Classification (ASJC) codes

  • Hepatology

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Complete response to treatment with hepatic arterial chemoembolization and arterial infusion chemotherapy in a case of hepatocellular carcinoma with multiple lung metastases. / Haruno, Masatora; Dohmen, Kazufumi; Oyama, Minako; Fukaura, Keita; Kubo, Norihiko; Tanaka, Hirofumi; Higashihara, Hideyuki; Okazaki, Masatoshi; Shimoda, Shinji.

In: Acta Hepatologica Japonica, Vol. 50, No. 4, 05.06.2009, p. 201-207.

Research output: Contribution to journalArticle

Haruno, Masatora ; Dohmen, Kazufumi ; Oyama, Minako ; Fukaura, Keita ; Kubo, Norihiko ; Tanaka, Hirofumi ; Higashihara, Hideyuki ; Okazaki, Masatoshi ; Shimoda, Shinji. / Complete response to treatment with hepatic arterial chemoembolization and arterial infusion chemotherapy in a case of hepatocellular carcinoma with multiple lung metastases. In: Acta Hepatologica Japonica. 2009 ; Vol. 50, No. 4. pp. 201-207.
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