Complex formation between cationic β-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to induce cytokine secretion

Masato Ikeda, Jusaku Minari, Naohiko Shimada, Munenori Numata, Kazuo Sakurai, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A cationic polysaccharide bearing a β-1,3-glucan main-chain structure (CUR-N+) forms a complex with a hetero-sequence oligonucleotide, that is, a CpG ODN, and facilitates the transportation of the resultant complex into a murine macrophage-like cell J774.A1, which induces an efficient secretion of a cytokine (IL-12) as compared with that induced by conventional carriers such as poly(ethyleneimine) (PEI) and poly(l-lysine) (PLL).

Original languageEnglish
Pages (from-to)2219-2224
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume5
Issue number14
DOIs
Publication statusPublished - Aug 2 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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