Complex karyotypic abnormality in an aged patient with acute myeloid leukemia (M 2)

K. Mimori, K. Kawauchi, H. Watanabe, H. Sugiyama

Research output: Contribution to journalArticle

Abstract

A 74-year-old man was admitted on November 1986 because of general fatigue. His peripheral blood showed pancytopenia without immature cells since December 1985. Hematological data showed RBC 150 X 10(4)/microliter, PLT 7,000/microliter, WBC 12,000/microliter with 93.6% leukemic cells. The bone marrow smear revealed NCC 14.5 x 10(4)/microliter with 76% leukemic cells. The leukemic cells were characterized by faint staining with peroxidase stain and strong positivity for CD 13 antigen determined with immunoperoxidase method and flow cytometric analysis. The chromosomal analysis of tumor cells represented as follows: 44, XY, -3, -4, -9, -20, 2q+, 6p-, 7q-, 12q+, +2 mar. Although remarkable reduction of leukemic cells in peripheral blood was obtained one month after initiation of 19-days intravenous continuous infusion of N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BHAC), he suffered from severe systemic candida infection with severe leukopenia and died. Not only advanced age but also complex karyotypic abnormality would contribute to failure of treatment in this case. The significance of complex karyotypic abnormality in acute non-lymphocytic leukemia in discussed based on the current literature.

Original languageEnglish
Pages (from-to)868-873
Number of pages6
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology
Volume30
Issue number6
Publication statusPublished - Jun 1 1989
Externally publishedYes

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Acute Myeloid Leukemia
CD Antigens
Mars
Pancytopenia
Cytarabine
Leukopenia
Treatment Failure
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intravenous Infusions
Peroxidase
Fatigue
Coloring Agents
Bone Marrow
Staining and Labeling
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Complex karyotypic abnormality in an aged patient with acute myeloid leukemia (M 2). / Mimori, K.; Kawauchi, K.; Watanabe, H.; Sugiyama, H.

In: [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 30, No. 6, 01.06.1989, p. 868-873.

Research output: Contribution to journalArticle

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