Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2: Its in vitro Evaluation

Chikara Ohtsuki, Yukio Kobayashi, Kanji Tsuru, Akiyoshi Osaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B2O3on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B2O3-SiO2was examined in the simulated body fluid. Substitution of small amounts of B2O3for SiO2in CaO • SiO2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mol% B2O3for SiO2 decreased it. The substitution of B2O3for SiO2in CaO~SiO2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B2O3for SiO2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalJournal of the Society of Materials Science, Japan
Volume44
Issue number501
DOIs
Publication statusPublished - Jan 1 1995

Fingerprint

Apatites
Apatite
Bioactivity
apatites
Glass
evaluation
glass
Substitution reactions
Glass ceramics
substitutes
Bone
bones
Hydrogel
Supersaturation
Body fluids
ceramics
Hydrogels
Silicon Dioxide
body fluids
boron oxide

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2 : Its in vitro Evaluation. / Ohtsuki, Chikara; Kobayashi, Yukio; Tsuru, Kanji; Osaka, Akiyoshi.

In: Journal of the Society of Materials Science, Japan, Vol. 44, No. 501, 01.01.1995, p. 693-699.

Research output: Contribution to journalArticle

Ohtsuki, Chikara ; Kobayashi, Yukio ; Tsuru, Kanji ; Osaka, Akiyoshi. / Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2 : Its in vitro Evaluation. In: Journal of the Society of Materials Science, Japan. 1995 ; Vol. 44, No. 501. pp. 693-699.
@article{c5aae39fdd214f158bc1cfc8fabb9ec3,
title = "Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2: Its in vitro Evaluation",
abstract = "The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B2O3on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B2O3-SiO2was examined in the simulated body fluid. Substitution of small amounts of B2O3for SiO2in CaO • SiO2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mol{\%} B2O3for SiO2 decreased it. The substitution of B2O3for SiO2in CaO~SiO2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B2O3for SiO2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.",
author = "Chikara Ohtsuki and Yukio Kobayashi and Kanji Tsuru and Akiyoshi Osaka",
year = "1995",
month = "1",
day = "1",
doi = "10.2472/jsms.44.693",
language = "English",
volume = "44",
pages = "693--699",
journal = "Zairyo/Journal of the Society of Materials Science, Japan",
issn = "0514-5163",
publisher = "公益社団法人 日本材料学会",
number = "501",

}

TY - JOUR

T1 - Compositional Dependence of Bioactivity of Glasses in the System CaO-B2O3-SiO2

T2 - Its in vitro Evaluation

AU - Ohtsuki, Chikara

AU - Kobayashi, Yukio

AU - Tsuru, Kanji

AU - Osaka, Akiyoshi

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B2O3on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B2O3-SiO2was examined in the simulated body fluid. Substitution of small amounts of B2O3for SiO2in CaO • SiO2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mol% B2O3for SiO2 decreased it. The substitution of B2O3for SiO2in CaO~SiO2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B2O3for SiO2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.

AB - The essential condition for glasses and glass-ceramics to bond to living bone is the formation of a biologically active bone-like apatite layer on their surfaces in the body. In the present study, in order to investigate fundamentally the effect of B2O3on the bioactivity of glasses and glass-ceramics, the compositional dependence of apatite formation on the surface of glasses in the system CaO-B2O3-SiO2was examined in the simulated body fluid. Substitution of small amounts of B2O3for SiO2in CaO • SiO2 formula increased the rate of apatite formation on the surface of the glass, while substitution of more than 30 mol% B2O3for SiO2 decreased it. The substitution of B2O3for SiO2in CaO~SiO2 binary glasses accelerated the dissolution of Ca(II) ion from the glasses, and hence enhanced the increasing rate of degree of supersaturation of the surrounding fluid with respect to apatite. The decrease in the apatite forming ability by substitution of large amounts of B2O3for SiO2 is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.

UR - http://www.scopus.com/inward/record.url?scp=0029328237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029328237&partnerID=8YFLogxK

U2 - 10.2472/jsms.44.693

DO - 10.2472/jsms.44.693

M3 - Article

AN - SCOPUS:0029328237

VL - 44

SP - 693

EP - 699

JO - Zairyo/Journal of the Society of Materials Science, Japan

JF - Zairyo/Journal of the Society of Materials Science, Japan

SN - 0514-5163

IS - 501

ER -