Comprehensive Analysis of Analogues of Amine-Related Psychoactive Substances Using Femtosecond Laser Ionization Mass Spectrometry

Siddihalu Lakshitha Madunil, Totaro Imasaka, Tomoko Imasaka

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    1 Citation (Scopus)

    Abstract

    Amine-related psychoactive molecules contain N–Cα and Cα–Cβ bonds, which easily dissociate to form various fragment ions in electron ionization mass spectrometry (EIMS). Therefore, observing a molecular ion and then determining the molecular weight of the analyte is difficult. In this study, we examined phenethylamine, 3,4-methylenedioxyphenethylamine, tryptamine, N-methylephedrine, and nicotine as well as analogues of amine-related psychoactive substances using EIMS and femtosecond laser ionization mass spectrometry (fs-LIMS) combined with gas chromatography for comprehensive analysis. A molecular ion was clearly observed in fs-LIMS for all of these compounds, which was in contrast to EIMS providing fragment ions dominantly (no molecular ion was observed for N-methylephedrine). This favorable result was obtained by adjusting the laser wavelength to the optimal value for two-photon ionization to minimize the excess energy remaining in the molecular ion. It therefore appears that fs-LIMS is superior to EIMS in terms of observing a molecular ion and would be potentially useful for identifying a variety of amine-related psychoactive substances, some of which are illegal and are of interest in the field of forensic science.

    Original languageEnglish
    Pages (from-to)90-99
    Number of pages10
    JournalJournal of the American Society for Mass Spectrometry
    Volume33
    Issue number1
    DOIs
    Publication statusPublished - Jan 5 2022

    All Science Journal Classification (ASJC) codes

    • Structural Biology
    • Spectroscopy

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