Comprehensive behavioural study of GluR4 knockout mice: Implication in cognitive function

N. Sagata, A. Iwaki, T. Aramaki, K. Takao, S. Kura, Teruhisa Tsuzuki, R. Kawakami, Isao Ito, T. Kitamura, H. Sugiyama, T. Miyakawa, Y. Fukumaki

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Fast excitatory transmission in the mammalian central nervous system is mediated by AMPA-type glutamate receptors. The tetrameric AMPA receptor complexes are composed of four subunits, GluR1-4. The GluR4 subunit is highly expressed in the cerebellum and the early postnatal hippocampus and is thought to be involved in synaptic plasticity and the development of functional neural circuitry through the recruitment of other AMPA receptor subunits. Previously, we reported an association of the human GluR4 gene (GRIA4) with schizophrenia. To examine the role of the GluR4 subunit in the higher brain function, we generated GluR4 knockout mice and conducted electrophysiological and behavioural analyses. The mutant mice showed normal long-term potentiation (LTP) in the CA1 region of the hippocampus. The GluR4 knockout mice showed mildly improved spatial working memory in the T-maze test. Although the retention of spatial reference memory was intact in the mutant mice, the acquisition of spatial reference memory was impaired in the Barnes circular maze test. The GluR4 knockout mice showed impaired prepulse inhibition. These results suggest the involvement of the GluR4 subunit in cognitive function.

Original languageEnglish
Pages (from-to)899-909
Number of pages11
JournalGenes, Brain and Behavior
Volume9
Issue number8
DOIs
Publication statusPublished - Nov 1 2010

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AMPA Receptors
Knockout Mice
Cognition
Hippocampus
Neuronal Plasticity
Long-Term Potentiation
Glutamate Receptors
Short-Term Memory
Cerebellum
Schizophrenia
Central Nervous System
Brain
Genes
Spatial Memory

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Sagata, N., Iwaki, A., Aramaki, T., Takao, K., Kura, S., Tsuzuki, T., ... Fukumaki, Y. (2010). Comprehensive behavioural study of GluR4 knockout mice: Implication in cognitive function. Genes, Brain and Behavior, 9(8), 899-909. https://doi.org/10.1111/j.1601-183X.2010.00629.x

Comprehensive behavioural study of GluR4 knockout mice : Implication in cognitive function. / Sagata, N.; Iwaki, A.; Aramaki, T.; Takao, K.; Kura, S.; Tsuzuki, Teruhisa; Kawakami, R.; Ito, Isao; Kitamura, T.; Sugiyama, H.; Miyakawa, T.; Fukumaki, Y.

In: Genes, Brain and Behavior, Vol. 9, No. 8, 01.11.2010, p. 899-909.

Research output: Contribution to journalArticle

Sagata, N, Iwaki, A, Aramaki, T, Takao, K, Kura, S, Tsuzuki, T, Kawakami, R, Ito, I, Kitamura, T, Sugiyama, H, Miyakawa, T & Fukumaki, Y 2010, 'Comprehensive behavioural study of GluR4 knockout mice: Implication in cognitive function', Genes, Brain and Behavior, vol. 9, no. 8, pp. 899-909. https://doi.org/10.1111/j.1601-183X.2010.00629.x
Sagata, N. ; Iwaki, A. ; Aramaki, T. ; Takao, K. ; Kura, S. ; Tsuzuki, Teruhisa ; Kawakami, R. ; Ito, Isao ; Kitamura, T. ; Sugiyama, H. ; Miyakawa, T. ; Fukumaki, Y. / Comprehensive behavioural study of GluR4 knockout mice : Implication in cognitive function. In: Genes, Brain and Behavior. 2010 ; Vol. 9, No. 8. pp. 899-909.
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