Comprehensive expression of wnt signaling pathway genes during development and maturation of the mouse cochlea

Ruishuang Geng, teppei noda, Joanna F. Mulvaney, Vincent Y.W. Lin, Albert S.B. Edge, Alain Dabdoub

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points. Results We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/ planar cell polarity. Conclusion A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.

Original languageEnglish
Article numbere0148339
JournalPloS one
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Wnt Signaling Pathway
Cochlea
Inner Ear
ears
Genes
mice
Cochlear Duct
Cell Proliferation
Stria Vascularis
cell proliferation
Cell Polarity
genes
Mesoderm
Ear
Regeneration
postpartum period
Homeostasis
Epithelium
Gene Expression
antagonists

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Comprehensive expression of wnt signaling pathway genes during development and maturation of the mouse cochlea. / Geng, Ruishuang; noda, teppei; Mulvaney, Joanna F.; Lin, Vincent Y.W.; Edge, Albert S.B.; Dabdoub, Alain.

In: PloS one, Vol. 11, No. 2, e0148339, 01.02.2016.

Research output: Contribution to journalArticle

Geng, Ruishuang ; noda, teppei ; Mulvaney, Joanna F. ; Lin, Vincent Y.W. ; Edge, Albert S.B. ; Dabdoub, Alain. / Comprehensive expression of wnt signaling pathway genes during development and maturation of the mouse cochlea. In: PloS one. 2016 ; Vol. 11, No. 2.
@article{3c532a0b5e474383add9dee6151a5b72,
title = "Comprehensive expression of wnt signaling pathway genes during development and maturation of the mouse cochlea",
abstract = "Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points. Results We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/ planar cell polarity. Conclusion A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.",
author = "Ruishuang Geng and teppei noda and Mulvaney, {Joanna F.} and Lin, {Vincent Y.W.} and Edge, {Albert S.B.} and Alain Dabdoub",
year = "2016",
month = "2",
day = "1",
doi = "10.1371/journal.pone.0148339",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Comprehensive expression of wnt signaling pathway genes during development and maturation of the mouse cochlea

AU - Geng, Ruishuang

AU - noda, teppei

AU - Mulvaney, Joanna F.

AU - Lin, Vincent Y.W.

AU - Edge, Albert S.B.

AU - Dabdoub, Alain

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points. Results We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/ planar cell polarity. Conclusion A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.

AB - Background In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points. Results We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/ planar cell polarity. Conclusion A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.

UR - http://www.scopus.com/inward/record.url?scp=84959431716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959431716&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0148339

DO - 10.1371/journal.pone.0148339

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e0148339

ER -