Computer-aided classification of Alzheimer's disease based on support vector machine with combination of cerebral image features in MRI

C. Jongkreangkrai, Y. Vichianin, C. Tocharoenchai, H. Arimura

Research output: Contribution to journalConference article

9 Citations (Scopus)

Abstract

Several studies have differentiated Alzheimer's disease (AD) using cerebral image features derived from MR brain images. In this study, we were interested in combining hippocampus and amygdala volumes and entorhinal cortex thickness to improve the performance of AD differentiation. Thus, our objective was to investigate the useful features obtained from MRI for classification of AD patients using support vector machine (SVM). T1-weighted MR brain images of 100 AD patients and 100 normal subjects were processed using FreeSurfer software to measure hippocampus and amygdala volumes and entorhinal cortex thicknesses in both brain hemispheres. Relative volumes of hippocampus and amygdala were calculated to correct variation in individual head size. SVM was employed with five combinations of features (H: hippocampus relative volumes, A: amygdala relative volumes, E: entorhinal cortex thicknesses, HA: hippocampus and amygdala relative volumes and ALL: all features). Receiver operating characteristic (ROC) analysis was used to evaluate the method. AUC values of five combinations were 0.8575 (H), 0.8374 (A), 0.8422 (E), 0.8631 (HA) and 0.8906 (ALL). Although "ALL" provided the highest AUC, there were no statistically significant differences among them except for "A" feature. Our results showed that all suggested features may be feasible for computer-aided classification of AD patients.

Original languageEnglish
Article number012036
JournalJournal of Physics: Conference Series
Volume694
Issue number1
DOIs
Publication statusPublished - Mar 24 2016
Event13th South-East Asian Congress of Medical Physics, SEACOMP 2015 - Yogyakarta, Indonesia
Duration: Dec 10 2015Dec 12 2015

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All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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