Computer-aided detection of multiple sclerosis lesions in brain magnetic resonance images: False positive reduction scheme consisted of rule-based, level set method, and support vector machine

Daisuke Yamamoto, Hidetaka Arimura, Shingo Kakeda, Taiki Magome, Yasuo Yamashita, Fukai Toyofuku, Masafumi Ohki, Yoshiharu Higashida, Yukunori Korogi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The purpose of this study was to develop a computerized method for detection of multiple sclerosis (MS) lesions in brain magnetic resonance (MR) images. We have proposed a new false positive reduction scheme, which consisted of a rule-based method, a level set method, and a support vector machine. We applied the proposed method to 49 slices selected from 6 studies of three MS cases including 168 MS lesions. As a result, the sensitivity for detection of MS lesions was 81.5% with 2.9 false positives per slice based on a leave-one-candidate-out test, and the similarity index between MS regions determined by the proposed method and neuroradiologists was 0.768 on average. These results indicate the proposed method would be useful for assisting neuroradiologists in assessing the MS in clinical practice.

Original languageEnglish
Pages (from-to)404-413
Number of pages10
JournalComputerized Medical Imaging and Graphics
Volume34
Issue number5
DOIs
Publication statusPublished - Jul 1 2010

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

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