Computer-assisted delineation of lung tumor regions in treatment planning CT images with PET/CT image sets based on an optimum contour selection method

Ze Jin, Hidetaka Arimura, Yoshiyuki Shioyama, Katsumasa Nakamura, Jumpei Kuwazuru, Taiki Magome, Hidetake Yabuuchi, Hiroshi Honda, Hideki Hirata, Masayuki Sasaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To assist radiation oncologists in the delineation of tumor regions during treatment planning for lung cancer, we have proposed an automated contouring algorithm based on an optimum contour selection (OCS) method for treatment planning computed tomography (CT) images with positron emission tomography (PET)/CT images. The basic concept of the OCS is to select a global optimum object contour based on multiple active delineations with a level set method around tumors. First, the PET images were registered to the planning CT images by using affine transformation matrices. The initial gross tumor volume (GTV) of each lung tumor was identified by thresholding the PET image at a certain standardized uptake value, and then each initial GTV location was corrected in the region of interest of the planning CT image. Finally, the contours of final GTV regions were determined in the planning CT images by using the OCS. The proposed method was evaluated by testing six cases with a Dice similarity coefficient (DSC), which denoted the degree of region similarity between the GTVs contoured by radiation oncologists and the proposed method. The average three-dimensional DSC for the six cases was 0.78 by the proposed method, but only 0.34 by a conventional method based on a simple level set method. The proposed method may be helpful for treatment planners in contouring the GTV regions.

Original languageEnglish
Pages (from-to)1153-1162
Number of pages10
JournalJournal of radiation research
Volume55
Issue number6
DOIs
Publication statusPublished - Nov 1 2014

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delineation
lungs
planning
positrons
tumors
tomography
Tomography
Lung
Tumor Burden
Neoplasms
Therapeutics
Positron-Emission Tomography
Positron Emission Tomography Computed Tomography
radiation
coefficients
Patient Selection
Lung Neoplasms
cancer

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Computer-assisted delineation of lung tumor regions in treatment planning CT images with PET/CT image sets based on an optimum contour selection method. / Jin, Ze; Arimura, Hidetaka; Shioyama, Yoshiyuki; Nakamura, Katsumasa; Kuwazuru, Jumpei; Magome, Taiki; Yabuuchi, Hidetake; Honda, Hiroshi; Hirata, Hideki; Sasaki, Masayuki.

In: Journal of radiation research, Vol. 55, No. 6, 01.11.2014, p. 1153-1162.

Research output: Contribution to journalArticle

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