Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan

Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Tsuguhide Hori, Kazuhiro Tobiishi, Daisuke Onozuka, Shizue Kato, Seiko Sasaki, Sonomi Nakajima, Yasuaki Saijo, Fumihiro Sata, Reiko Kishi, Takao Iida, Masutaka Furue

Research output: Contribution to journalArticle

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Abstract

We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho coplanar polychlorinated biphenyls (non-ortho PCBs), and mono-ortho coplanar polychlorinated biphenyls (mono-ortho PCBs) in blood collected between 2002 and 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which PCDDs, PCDFs, and dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years) and 94 were multipara (mean: 32.4 years). The arithmetic mean total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs of primiparous and multiparous mothers in Sapporo City were 17.4 (median: 15.7) and 14.0 (median: 13.9) pg TEQ/g lipid, respectively, and the concentrations were in the range of 6.6-43.4 and 3.4-28.2 pg TEQ/g lipid, respectively. In regard to the relationship between the total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in maternal blood and the number of deliveries or age of primiparous and multiparius mothers, the levels of these dioxin-like compounds tended to decrease with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total TEQ concentrations of these dioxin-like compounds and the age of primiparae and multiparae. The total TEQ concentration of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs measured in 195 pregnant women has decreased compared to past levels in Japan for the last several decades. The results of the present study have indicated that dioxin contamination in the blood of young women in Japan is continuing to decrease.

Original languageEnglish
Pages (from-to)1228-1237
Number of pages10
JournalChemosphere
Volume69
Issue number8
DOIs
Publication statusPublished - Oct 1 2007

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Dioxins
Polychlorinated Biphenyls
PCDF
Polychlorinated biphenyls
dioxin
Pregnant Women
PCB
Japan
Blood
blood
Mothers
Lipids
lipid
Polychlorinated Dibenzofurans
Polychlorinated Dibenzodioxins
city
woman
dibenzo(1,4)dioxin
Maternal Age
Contamination

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan. / Todaka, Takashi; Hirakawa, Hironori; Kajiwara, Jumboku; Hori, Tsuguhide; Tobiishi, Kazuhiro; Onozuka, Daisuke; Kato, Shizue; Sasaki, Seiko; Nakajima, Sonomi; Saijo, Yasuaki; Sata, Fumihiro; Kishi, Reiko; Iida, Takao; Furue, Masutaka.

In: Chemosphere, Vol. 69, No. 8, 01.10.2007, p. 1228-1237.

Research output: Contribution to journalArticle

Todaka, T, Hirakawa, H, Kajiwara, J, Hori, T, Tobiishi, K, Onozuka, D, Kato, S, Sasaki, S, Nakajima, S, Saijo, Y, Sata, F, Kishi, R, Iida, T & Furue, M 2007, 'Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan', Chemosphere, vol. 69, no. 8, pp. 1228-1237. https://doi.org/10.1016/j.chemosphere.2007.05.083
Todaka, Takashi ; Hirakawa, Hironori ; Kajiwara, Jumboku ; Hori, Tsuguhide ; Tobiishi, Kazuhiro ; Onozuka, Daisuke ; Kato, Shizue ; Sasaki, Seiko ; Nakajima, Sonomi ; Saijo, Yasuaki ; Sata, Fumihiro ; Kishi, Reiko ; Iida, Takao ; Furue, Masutaka. / Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan. In: Chemosphere. 2007 ; Vol. 69, No. 8. pp. 1228-1237.
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abstract = "We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho coplanar polychlorinated biphenyls (non-ortho PCBs), and mono-ortho coplanar polychlorinated biphenyls (mono-ortho PCBs) in blood collected between 2002 and 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which PCDDs, PCDFs, and dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years) and 94 were multipara (mean: 32.4 years). The arithmetic mean total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs of primiparous and multiparous mothers in Sapporo City were 17.4 (median: 15.7) and 14.0 (median: 13.9) pg TEQ/g lipid, respectively, and the concentrations were in the range of 6.6-43.4 and 3.4-28.2 pg TEQ/g lipid, respectively. In regard to the relationship between the total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in maternal blood and the number of deliveries or age of primiparous and multiparius mothers, the levels of these dioxin-like compounds tended to decrease with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total TEQ concentrations of these dioxin-like compounds and the age of primiparae and multiparae. The total TEQ concentration of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs measured in 195 pregnant women has decreased compared to past levels in Japan for the last several decades. The results of the present study have indicated that dioxin contamination in the blood of young women in Japan is continuing to decrease.",
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T1 - Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan

AU - Todaka, Takashi

AU - Hirakawa, Hironori

AU - Kajiwara, Jumboku

AU - Hori, Tsuguhide

AU - Tobiishi, Kazuhiro

AU - Onozuka, Daisuke

AU - Kato, Shizue

AU - Sasaki, Seiko

AU - Nakajima, Sonomi

AU - Saijo, Yasuaki

AU - Sata, Fumihiro

AU - Kishi, Reiko

AU - Iida, Takao

AU - Furue, Masutaka

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N2 - We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho coplanar polychlorinated biphenyls (non-ortho PCBs), and mono-ortho coplanar polychlorinated biphenyls (mono-ortho PCBs) in blood collected between 2002 and 2004 from 195 pregnant women living in Sapporo City of Hokkaido Prefecture, Japan. The present study is one of the few studies in which PCDDs, PCDFs, and dioxin-like PCBs have been measured in the blood of pregnant women. Of the 195 pregnant women, 101 were primipara (mean: 28.8 years) and 94 were multipara (mean: 32.4 years). The arithmetic mean total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs of primiparous and multiparous mothers in Sapporo City were 17.4 (median: 15.7) and 14.0 (median: 13.9) pg TEQ/g lipid, respectively, and the concentrations were in the range of 6.6-43.4 and 3.4-28.2 pg TEQ/g lipid, respectively. In regard to the relationship between the total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in maternal blood and the number of deliveries or age of primiparous and multiparius mothers, the levels of these dioxin-like compounds tended to decrease with increases in the number of deliveries and significantly increased with increasing maternal age in both groups. Furthermore, significant correlations were observed between the total TEQ concentrations of these dioxin-like compounds and the age of primiparae and multiparae. The total TEQ concentration of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs measured in 195 pregnant women has decreased compared to past levels in Japan for the last several decades. The results of the present study have indicated that dioxin contamination in the blood of young women in Japan is continuing to decrease.

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