Concurrent antipsychotic use in older adults treated with antidepressants in Asia

Min Dong, Liang Nan Zeng, Qinge Zhang, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Tian Mei Si, Kang Sim, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Kok Yoon Chee, Shigenobu Kanba, Min Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy A. Kallivayalil, Andi J. Tanra, Margarita M. Maramis, Winston W. ShenNorman Sartorius, Rathi Mahendran, Chay Hoon Tan, Naotaka Shinfuku, Yu Tao Xiang

Research output: Contribution to journalArticle

Abstract

Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalPsychogeriatrics
Volume19
Issue number4
DOIs
Publication statusPublished - Jul 1 2019

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Antidepressive Agents
Antipsychotic Agents
Psychiatry
Inpatients
Logistic Models
Regression Analysis
Korea
Depressive Disorder
Taiwan
Mental Disorders
Population
Multicenter Studies
Schizophrenia
Outpatients
Anxiety
Databases
Safety

All Science Journal Classification (ASJC) codes

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Dong, M., Zeng, L. N., Zhang, Q., Ungvari, G. S., Ng, C. H., Chiu, H. F. K., ... Xiang, Y. T. (2019). Concurrent antipsychotic use in older adults treated with antidepressants in Asia. Psychogeriatrics, 19(4), 333-339. https://doi.org/10.1111/psyg.12416

Concurrent antipsychotic use in older adults treated with antidepressants in Asia. / Dong, Min; Zeng, Liang Nan; Zhang, Qinge; Ungvari, Gabor S.; Ng, Chee H.; Chiu, Helen F.K.; Si, Tian Mei; Sim, Kang; Avasthi, Ajit; Grover, Sandeep; Chong, Mian Yoon; Chee, Kok Yoon; Kanba, Shigenobu; Lee, Min Soo; Yang, Shu Yu; Udomratn, Pichet; Kallivayalil, Roy A.; Tanra, Andi J.; Maramis, Margarita M.; Shen, Winston W.; Sartorius, Norman; Mahendran, Rathi; Tan, Chay Hoon; Shinfuku, Naotaka; Xiang, Yu Tao.

In: Psychogeriatrics, Vol. 19, No. 4, 01.07.2019, p. 333-339.

Research output: Contribution to journalArticle

Dong, M, Zeng, LN, Zhang, Q, Ungvari, GS, Ng, CH, Chiu, HFK, Si, TM, Sim, K, Avasthi, A, Grover, S, Chong, MY, Chee, KY, Kanba, S, Lee, MS, Yang, SY, Udomratn, P, Kallivayalil, RA, Tanra, AJ, Maramis, MM, Shen, WW, Sartorius, N, Mahendran, R, Tan, CH, Shinfuku, N & Xiang, YT 2019, 'Concurrent antipsychotic use in older adults treated with antidepressants in Asia', Psychogeriatrics, vol. 19, no. 4, pp. 333-339. https://doi.org/10.1111/psyg.12416
Dong M, Zeng LN, Zhang Q, Ungvari GS, Ng CH, Chiu HFK et al. Concurrent antipsychotic use in older adults treated with antidepressants in Asia. Psychogeriatrics. 2019 Jul 1;19(4):333-339. https://doi.org/10.1111/psyg.12416
Dong, Min ; Zeng, Liang Nan ; Zhang, Qinge ; Ungvari, Gabor S. ; Ng, Chee H. ; Chiu, Helen F.K. ; Si, Tian Mei ; Sim, Kang ; Avasthi, Ajit ; Grover, Sandeep ; Chong, Mian Yoon ; Chee, Kok Yoon ; Kanba, Shigenobu ; Lee, Min Soo ; Yang, Shu Yu ; Udomratn, Pichet ; Kallivayalil, Roy A. ; Tanra, Andi J. ; Maramis, Margarita M. ; Shen, Winston W. ; Sartorius, Norman ; Mahendran, Rathi ; Tan, Chay Hoon ; Shinfuku, Naotaka ; Xiang, Yu Tao. / Concurrent antipsychotic use in older adults treated with antidepressants in Asia. In: Psychogeriatrics. 2019 ; Vol. 19, No. 4. pp. 333-339.
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AU - Zeng, Liang Nan

AU - Zhang, Qinge

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AU - Chiu, Helen F.K.

AU - Si, Tian Mei

AU - Sim, Kang

AU - Avasthi, Ajit

AU - Grover, Sandeep

AU - Chong, Mian Yoon

AU - Chee, Kok Yoon

AU - Kanba, Shigenobu

AU - Lee, Min Soo

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AU - Kallivayalil, Roy A.

AU - Tanra, Andi J.

AU - Maramis, Margarita M.

AU - Shen, Winston W.

AU - Sartorius, Norman

AU - Mahendran, Rathi

AU - Tan, Chay Hoon

AU - Shinfuku, Naotaka

AU - Xiang, Yu Tao

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N2 - Aim: Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods: This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results: A total of 955 older adult psychiatric in- and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion: Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.

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