Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma

Akira Nakamizo, Satoshi Suzuki, Takafumi Shimogawa, Toshiyuki Amano, Masahiro Mizoguchi, Koji Yoshimoto, Tomio Sasaki

Research output: Contribution to journalArticle

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Abstract

We present a first case of concurrent tumors consisting of schwannoma and meningioma arising at the same spinal level in a patient without neurofibromatosis. A 49-year-old man without clinical evidence of neurofibromatosis presented with a 5-month history of right neck pain. MRI demonstrated an extradural tumor involving the right-sided C2 nerve root with a small intradural component. T1- and T2-weighted and contrast-enhanced MRI could not differentiate the intradural tumor as different from the extradural tumor. Total removal of the tumors was performed. No contiguity of the extradural tumor with the intradural tumor was seen. The intradural tumor attached strongly to the dura mater around the C2 nerve root exits. Intraoperative pathological diagnosis confirmed the extradural tumor as schwannoma and the intradural tumor as meningioma. We therefore thoroughly coagulated the dura mater adjacent to the intradural tumor and resected the dura mater around the nerve root exits together with the tumor. Pathological examination revealed that the resection edge of the extradural component consisted of a spinal nerve with thickened epineurium and was free of neoplastic cells. No schwannoma component was evident in the intradural tumor. No obvious transition thus existed between the extra- and intradural tumors. Distinguishing these tumors prior to surgery is critical for determining an optimal surgical plan, as schwannoma and meningioma require different surgical procedures. We therefore recommend a careful review of preoperative imaging with the possibility of concurrent tumors in mind.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalNeuropathology
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

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Spinal Nerve Roots
Neurilemmoma
Meningioma
Neoplasms
Dura Mater
Neurofibromatoses
Spinal Nerves
Neck Pain
Peripheral Nerves

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma. / Nakamizo, Akira; Suzuki, Satoshi; Shimogawa, Takafumi; Amano, Toshiyuki; Mizoguchi, Masahiro; Yoshimoto, Koji; Sasaki, Tomio.

In: Neuropathology, Vol. 32, No. 2, 01.04.2012, p. 190-195.

Research output: Contribution to journalArticle

Nakamizo, Akira ; Suzuki, Satoshi ; Shimogawa, Takafumi ; Amano, Toshiyuki ; Mizoguchi, Masahiro ; Yoshimoto, Koji ; Sasaki, Tomio. / Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma. In: Neuropathology. 2012 ; Vol. 32, No. 2. pp. 190-195.
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