Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes

Eriko Sasaki, Joanna Gunis, Ilka Reichardt-Gomez, Viktoria Nizhynska, Magnus Nordborg

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture—once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization.

Original languageEnglish
Article numbere1010345
JournalPLoS genetics
Volume18
Issue number9
DOIs
Publication statusPublished - Sep 9 2022

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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