TY - JOUR
T1 - Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes
AU - Sasaki, Eriko
AU - Gunis, Joanna
AU - Reichardt-Gomez, Ilka
AU - Nizhynska, Viktoria
AU - Nordborg, Magnus
N1 - Publisher Copyright:
Copyright: © 2022 Sasaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/9/9
Y1 - 2022/9/9
N2 - Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture—once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization.
AB - Genome-wide association studies (GWAS) have revealed that the striking natural variation for DNA CHH-methylation (mCHH; H is A, T, or C) of transposons has oligogenic architecture involving major alleles at a handful of known methylation regulators. Here we use a conditional GWAS approach to show that CHG-methylation (mCHG) has a similar genetic architecture—once mCHH is statistically controlled for. We identify five key trans-regulators that appear to modulate mCHG levels, and show that they interact with a previously identified modifier of mCHH in regulating natural transposon mobilization.
UR - http://www.scopus.com/inward/record.url?scp=85138086464&partnerID=8YFLogxK
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U2 - 10.1371/journal.pgen.1010345
DO - 10.1371/journal.pgen.1010345
M3 - Article
C2 - 36084135
AN - SCOPUS:85138086464
VL - 18
JO - PLoS Genetics
JF - PLoS Genetics
SN - 1553-7390
IS - 9
M1 - e1010345
ER -
