Conditioning with cyclophosphamide/antithymocyte globulin for allogeneic bone marrow transplantation from HLA-matched siblings in children with severe aplastic anemia

E. Azuma, S. Kojima, K. Kato, T. Matsuyama, Y. Yamada, N. Kondo, H. Sawada, M. Hanada, T. Shibata, N. Tabata, M. Watanabe, Y. Shimono, T. Deguchi, M. Umemoto, M. Higashikawa, H. Kawasaki, Y. Komada, M. Sakurai

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.

Original languageEnglish
Pages (from-to)1085-1087
Number of pages3
JournalBone Marrow Transplantation
Volume19
Issue number11
DOIs
Publication statusPublished - Jun 1 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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