Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male

Eriko Sada, Hideho Henzan, Ryoko Ohtani, Ken Takase, Toshihiro Miyamoto, Takahiro Fukuda, Koji Nagafuji, Keita Yamauchi, Yasushi Takamatsu, Shoichi Inaba, Mine Harada

Research output: Contribution to journalArticle

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Abstract

We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalAmerican Journal of Hematology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

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Peripheral Blood Stem Cell Transplantation
Busulfan
Acute Myeloid Leukemia
Hepatic Insufficiency
Cytarabine
Granulocyte Colony-Stimulating Factor
Etoposide
Renal Insufficiency
Leukemia
Drug Therapy
XYY syndrome 47

All Science Journal Classification (ASJC) codes

  • Hematology

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Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male. / Sada, Eriko; Henzan, Hideho; Ohtani, Ryoko; Takase, Ken; Miyamoto, Toshihiro; Fukuda, Takahiro; Nagafuji, Koji; Yamauchi, Keita; Takamatsu, Yasushi; Inaba, Shoichi; Harada, Mine.

In: American Journal of Hematology, Vol. 78, No. 1, 01.01.2005, p. 55-58.

Research output: Contribution to journalArticle

Sada, E, Henzan, H, Ohtani, R, Takase, K, Miyamoto, T, Fukuda, T, Nagafuji, K, Yamauchi, K, Takamatsu, Y, Inaba, S & Harada, M 2005, 'Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male', American Journal of Hematology, vol. 78, no. 1, pp. 55-58. https://doi.org/10.1002/ajh.20255
Sada, Eriko ; Henzan, Hideho ; Ohtani, Ryoko ; Takase, Ken ; Miyamoto, Toshihiro ; Fukuda, Takahiro ; Nagafuji, Koji ; Yamauchi, Keita ; Takamatsu, Yasushi ; Inaba, Shoichi ; Harada, Mine. / Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male. In: American Journal of Hematology. 2005 ; Vol. 78, No. 1. pp. 55-58.
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