Conformational analysis of an anxiolytic agent: Tandospirone in aqueous solution

Jun Etsu Igarashi; Tamiki Nishimura; Makoto Sunagawa

doi:10.1016/S0960-894X(97)00289-8

Conformational analysis of an anxiolytic agent: Tandospirone in aqueous solution

Jun Etsu Igarashi, Tamiki Nishimura, Makoto Sunagawa

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The conformations of tandospirone (la) and related compounds in aqueous solution have been studied by ¹H NMR, 1R experiments and MM calculations. The significant contribution to the folded conformer of tandospirone was found in aqueous solution.

Original language	English
Pages (from-to)	1659-1664
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(97)00289-8
Publication status	Published - Jul 8 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00289-8

Cite this

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title = "Conformational analysis of an anxiolytic agent: Tandospirone in aqueous solution",

abstract = "The conformations of tandospirone (la) and related compounds in aqueous solution have been studied by 1H NMR, 1R experiments and MM calculations. The significant contribution to the folded conformer of tandospirone was found in aqueous solution.",

author = "Igarashi, {Jun Etsu} and Tamiki Nishimura and Makoto Sunagawa",

year = "1997",

month = jul,

day = "8",

doi = "10.1016/S0960-894X(97)00289-8",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Conformational analysis of an anxiolytic agent

T2 - Tandospirone in aqueous solution

AU - Igarashi, Jun Etsu

AU - Nishimura, Tamiki

AU - Sunagawa, Makoto

PY - 1997/7/8

Y1 - 1997/7/8

N2 - The conformations of tandospirone (la) and related compounds in aqueous solution have been studied by 1H NMR, 1R experiments and MM calculations. The significant contribution to the folded conformer of tandospirone was found in aqueous solution.

AB - The conformations of tandospirone (la) and related compounds in aqueous solution have been studied by 1H NMR, 1R experiments and MM calculations. The significant contribution to the folded conformer of tandospirone was found in aqueous solution.

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UR - http://www.scopus.com/inward/citedby.url?scp=0030858726&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(97)00289-8

DO - 10.1016/S0960-894X(97)00289-8

M3 - Article

AN - SCOPUS:0030858726

SN - 0960-894X

VL - 7

SP - 1659

EP - 1664

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Conformational analysis of an anxiolytic agent: Tandospirone in aqueous solution

Abstract

All Science Journal Classification (ASJC) codes

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