Conformational analysis of an anxiolytic agent: Tandospirone in aqueous solution

Jun Etsu Igarashi, Tamiki Nishimura, Makoto Sunagawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The conformations of tandospirone (la) and related compounds in aqueous solution have been studied by 1H NMR, 1R experiments and MM calculations. The significant contribution to the folded conformer of tandospirone was found in aqueous solution.

Original languageEnglish
Pages (from-to)1659-1664
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number13
DOIs
Publication statusPublished - Jul 8 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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