Conformational analysis of meropenem and desmethyl meropenem: The effect of 1β-methyl group on carbapenem antibiotics

Jun Etsu Igarashi; Tamiki Nishimura; Akira Sasaki; Makoto Sunagawa

doi:10.1016/0960-894X(96)00341-1

Conformational analysis of meropenem and desmethyl meropenem: The effect of 1β-methyl group on carbapenem antibiotics

Jun Etsu Igarashi, Tamiki Nishimura, Akira Sasaki, Makoto Sunagawa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and ¹H NMR experiments. It was found that the preferred conformation of meropenem was relatively linear compared with desmethyl meropenem in aqueous solution.

Original language	English
Pages (from-to)	1881-1886
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	16
DOIs	https://doi.org/10.1016/0960-894X(96)00341-1
Publication status	Published - Aug 20 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/0960-894X(96)00341-1

Cite this

@article{69c6ae340fff47f4a1e060f4165cee2a,

title = "Conformational analysis of meropenem and desmethyl meropenem: The effect of 1β-methyl group on carbapenem antibiotics",

abstract = "The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and 1H NMR experiments. It was found that the preferred conformation of meropenem was relatively linear compared with desmethyl meropenem in aqueous solution.",

author = "Igarashi, {Jun Etsu} and Tamiki Nishimura and Akira Sasaki and Makoto Sunagawa",

year = "1996",

month = aug,

day = "20",

doi = "10.1016/0960-894X(96)00341-1",

language = "English",

volume = "6",

pages = "1881--1886",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "16",

}

TY - JOUR

T1 - Conformational analysis of meropenem and desmethyl meropenem

T2 - The effect of 1β-methyl group on carbapenem antibiotics

AU - Igarashi, Jun Etsu

AU - Nishimura, Tamiki

AU - Sasaki, Akira

AU - Sunagawa, Makoto

PY - 1996/8/20

Y1 - 1996/8/20

N2 - The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and 1H NMR experiments. It was found that the preferred conformation of meropenem was relatively linear compared with desmethyl meropenem in aqueous solution.

AB - The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and 1H NMR experiments. It was found that the preferred conformation of meropenem was relatively linear compared with desmethyl meropenem in aqueous solution.

UR - http://www.scopus.com/inward/record.url?scp=0030594997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030594997&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(96)00341-1

DO - 10.1016/0960-894X(96)00341-1

M3 - Article

AN - SCOPUS:0030594997

SN - 0960-894X

VL - 6

SP - 1881

EP - 1886

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Conformational analysis of meropenem and desmethyl meropenem: The effect of 1β-methyl group on carbapenem antibiotics

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this