Conformational analysis of meropenem and desmethyl meropenem: The effect of 1β-methyl group on carbapenem antibiotics

Jun Etsu Igarashi, Tamiki Nishimura, Akira Sasaki, Makoto Sunagawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and 1H NMR experiments. It was found that the preferred conformation of meropenem was relatively linear compared with desmethyl meropenem in aqueous solution.

Original languageEnglish
Pages (from-to)1881-1886
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number16
DOIs
Publication statusPublished - Aug 20 1996
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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