Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands

Tamiki Nishimura, Jun etsu Igarashi, Makoto Sunagawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.

Original languageEnglish
Pages (from-to)1141-1144
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number9
DOIs
Publication statusPublished - May 7 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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