Congenital hypoplastic trigeminal nerve revealed by manifestation of corneal disorders likely caused by neural factor deficiency

Naoyuki Morishige, Yukiko Morita, Naoyuki Yamada, Teruo Nishida, Koh Hei Sonoda

Research output: Contribution to journalArticle

3 Citations (Scopus)


Purpose: To report a case of hypoplastic trigeminal nerve associated with corneal epithelial disorders that were successfully treated with peptides derived from substance P and insulin-like growth factor-1 (IGF-1). Case Report: A 16-month-old boy was referred for treatment of a persistent corneal epithelial defect on his left eye. Magnetic resonance imaging revealed the apparent absence of the trigeminal nerve on the left side, and the patient was therefore diagnosed with neurotrophic keratopathy. Treatment with eye drops containing the tetrapeptides FGLM-NH2 and SSSR derived from the neuropeptide substance P and the growth factor IGF-1, respectively, resulted in resurfacing of the corneal epithelial defect. Discussion: The trigeminal nerve anomaly of the patient likely gave rise to neurotrophic keratopathy as a result of a deficiency of neural factors, emphasizing the importance of neural regulation in corneal epithelial homeostasis.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCase Reports in Ophthalmology
Issue number2
Publication statusPublished - May 22 2014


All Science Journal Classification (ASJC) codes

  • Ophthalmology

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