Conjugated linoleic acid reduces body fats and cytokine levels of mice

Asuka Akahoshi; Yuki Goto; Kayoko Murao; Tomoko Miyazaki; Masao Yamasaki; Michiko Nonaka; Koji Yamada; Michihiro Sugano

doi:10.1271/bbb.66.916

Conjugated linoleic acid reduces body fats and cytokine levels of mice

Asuka Akahoshi, Yuki Goto, Kayoko Murao, Tomoko Miyazaki, Masao Yamasaki, Michiko Nonaka, Koji Yamada, Michihiro Sugano

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

Original language	English
Pages (from-to)	916-920
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	66
Issue number	4
DOIs	https://doi.org/10.1271/bbb.66.916
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Conjugated linoleic acid reduces body fats and cytokine levels of mice",

abstract = "In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.",

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T1 - Conjugated linoleic acid reduces body fats and cytokine levels of mice

AU - Akahoshi, Asuka

AU - Goto, Yuki

AU - Murao, Kayoko

AU - Miyazaki, Tomoko

AU - Yamasaki, Masao

AU - Nonaka, Michiko

AU - Yamada, Koji

AU - Sugano, Michihiro

PY - 2002

Y1 - 2002

N2 - In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

AB - In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

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Conjugated linoleic acid reduces body fats and cytokine levels of mice

Abstract

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