Conjugated linoleic acid reduces body fats and cytokine levels of mice

Asuka Akahoshi, Yuki Goto, Kayoko Murao, Tomoko Miyazaki, Masao Yamasaki, Michiko Nonaka, Koji Yamada, Michihiro Sugano

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58 Citations (Scopus)

Abstract

In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced relative weights (g/100 g body weight) of epididymal and perirenal adipose tissues, in particular the former. Concentrations of serum TNF-α and leptin were significantly reduced by dietary CLA. Sesamin did not show additional effects in all of these parameters. There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned.

Original languageEnglish
Pages (from-to)916-920
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume66
Issue number4
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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    Akahoshi, A., Goto, Y., Murao, K., Miyazaki, T., Yamasaki, M., Nonaka, M., Yamada, K., & Sugano, M. (2002). Conjugated linoleic acid reduces body fats and cytokine levels of mice. Bioscience, Biotechnology and Biochemistry, 66(4), 916-920. https://doi.org/10.1271/bbb.66.916