Connecting threads: Epigenetics and metabolism

Sayako Katada, Axel Imhof, Paolo Sassone-Corsi

Research output: Contribution to journalShort survey

172 Citations (Scopus)

Abstract

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable patterns of gene expression. The challenge will now be to understand how localized fluctuations in levels of metabolites control chromatin modifiers in space and time, translating a dynamic metabolic state into a histone map.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalCell
Volume148
Issue number1-2
DOIs
Publication statusPublished - Jan 20 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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