Connection between periodontitis and Alzheimer's disease

Possible roles of microglia and leptomeningeal cells

Hiro Take, Hiroshi Nakanishi

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Neuroinflammation, inflammation of the brain, is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation. Therefore, the initiation and progression of AD are affected by systemic diseases such as cardiovascular disease and diabetes. This concept suggests a possible link between periodontitis and AD because periodontitis is a peripheral, chronic infection that elicits a significant systemic inflammatory response. There is now growing clinical evidence that chronic periodontitis is closely linked to the initiation and progression of AD. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to the brain-resident microglia, which in turn initiate neuroinflammation. Furthermore, it is apparent that senescent-type microglia respond in an exaggerated manner to systemic inflammation. It is estimated that a high percentage of adults are suffering from periodontitis, and the prevalence of periodontitis increases with age. Therefore, chronic periodontitis can be a significant source of covert systemic inflammation within the general population. The present review article highlights our current understanding of the link between periodontitis and AD.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalJournal of Pharmacological Sciences
Volume126
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

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Periodontitis
Microglia
Alzheimer Disease
Chronic Periodontitis
Inflammation
Encephalitis
Cardiovascular Diseases
Brain
Infection
Population

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Connection between periodontitis and Alzheimer's disease : Possible roles of microglia and leptomeningeal cells. / Take, Hiro; Nakanishi, Hiroshi.

In: Journal of Pharmacological Sciences, Vol. 126, No. 1, 01.01.2014, p. 8-13.

Research output: Contribution to journalReview article

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