Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: Central pathologic review and treatment outcome

Tsunehisa Kaku, Hiroyuki Yoshikawa, Hitoshi Tsuda, Atsuhiko Sakamoto, Masaharu Fukunaga, Yoshinori Kuwabara, Masaki Hataeg, Shoji Kodama, Kazuo Kuzuya, Shinji Sato, Toshinobu Nishimura, Masamichi Hiura, Hitoo Nakano, Tsuyoshi Iwasaka, Koji Miyazaki, Toshiharu Kamura

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Abstract

Thirty-nine patients with endometrioid adenocarcinoma (EA) and atypical hyperplasia (AH) of the endometrium who received conservative treatment to preserve fertility were collected from member institutions of the Japan Gynecologic Oncology Study Group. Twenty-nine and ten were originally diagnosed with EA without myometrial invasion and AH, respectively. We performed a central pathological review to make definite diagnoses, and the diagnosis of EA in 29 cases was changed to AH in ten, complex hyperplasia in three and atypical polypoid adenomyoma in three, and AH in ten was changed to EA in one and simple hyperplasia in one. Nine of 12 women (75%) with EA and 15 of 18 women (83%) with AH had an initial response to medroxyprogesterone acetate (MPA) treatment. Two of nine responders with EA later developed relapse, and one of them had metastasis to the left obturator lymph node. Two became pregnant, and one delivered one full-term infant. One of the responders with AH had a relapse in the endometrium. Five became pregnant, and four delivered four normal infants. The young women with endometrial carcinoma localized in the endometrium who wish to preserve fertility may be treated as successfully with MPA as those with AH.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalCancer Letters
Volume167
Issue number1
DOIs
Publication statusPublished - Jun 10 2001

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Endometrial Hyperplasia
Endometrium
Endometrioid Carcinoma
Hyperplasia
Adenocarcinoma
Medroxyprogesterone Acetate
Fertility
Adenomyoma
Conservative Treatment
Recurrence
Endometrial Neoplasms
Japan
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women : Central pathologic review and treatment outcome. / Kaku, Tsunehisa; Yoshikawa, Hiroyuki; Tsuda, Hitoshi; Sakamoto, Atsuhiko; Fukunaga, Masaharu; Kuwabara, Yoshinori; Hataeg, Masaki; Kodama, Shoji; Kuzuya, Kazuo; Sato, Shinji; Nishimura, Toshinobu; Hiura, Masamichi; Nakano, Hitoo; Iwasaka, Tsuyoshi; Miyazaki, Koji; Kamura, Toshiharu.

In: Cancer Letters, Vol. 167, No. 1, 10.06.2001, p. 39-48.

Research output: Contribution to journalArticle

Kaku, T, Yoshikawa, H, Tsuda, H, Sakamoto, A, Fukunaga, M, Kuwabara, Y, Hataeg, M, Kodama, S, Kuzuya, K, Sato, S, Nishimura, T, Hiura, M, Nakano, H, Iwasaka, T, Miyazaki, K & Kamura, T 2001, 'Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: Central pathologic review and treatment outcome', Cancer Letters, vol. 167, no. 1, pp. 39-48. https://doi.org/10.1016/S0304-3835(01)00462-1
Kaku, Tsunehisa ; Yoshikawa, Hiroyuki ; Tsuda, Hitoshi ; Sakamoto, Atsuhiko ; Fukunaga, Masaharu ; Kuwabara, Yoshinori ; Hataeg, Masaki ; Kodama, Shoji ; Kuzuya, Kazuo ; Sato, Shinji ; Nishimura, Toshinobu ; Hiura, Masamichi ; Nakano, Hitoo ; Iwasaka, Tsuyoshi ; Miyazaki, Koji ; Kamura, Toshiharu. / Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women : Central pathologic review and treatment outcome. In: Cancer Letters. 2001 ; Vol. 167, No. 1. pp. 39-48.
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