Conserved amino acid residues in ribosome-inactivating proteins from plants

G. Funatsu, MR Islam, Y. Minami, K. Sung-Sil, Makoto Kimura

Research output: Contribution to journalArticle

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Abstract

The amino acid sequences of eleeven RIPs sequenced to date have been compared in the expectation that this would be useful in the location of functionally and/or structurally important sites of these molecules. In addition to several highly conserved hydrophobic amino acids, thirteen absolutely conserved residues have been found in ricin A-chain: Tyr21, Phe24, Arg29, Tyr80, Tyr123, Gly140, Ala165, Glu177, Ala178, Glu208, Asn209 and Trp211. The role of these residues as well as of the C-terminal region have been discussed based on the results of chemical and enzymatic modifications, site-directed mutagenesis, and deletion studies.

Original languageEnglish
Pages (from-to)1157-1161
Number of pages5
JournalBiochimie
Volume73
Issue number7-8
DOIs
Publication statusPublished - Jan 1 1991

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Ribosome Inactivating Proteins
Ricin
Site-Directed Mutagenesis
Amino Acid Sequence
Amino Acids
Mutagenesis
Molecules

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Funatsu, G., Islam, MR., Minami, Y., Sung-Sil, K., & Kimura, M. (1991). Conserved amino acid residues in ribosome-inactivating proteins from plants. Biochimie, 73(7-8), 1157-1161. https://doi.org/10.1016/0300-9084(91)90160-3

Conserved amino acid residues in ribosome-inactivating proteins from plants. / Funatsu, G.; Islam, MR; Minami, Y.; Sung-Sil, K.; Kimura, Makoto.

In: Biochimie, Vol. 73, No. 7-8, 01.01.1991, p. 1157-1161.

Research output: Contribution to journalArticle

Funatsu, G, Islam, MR, Minami, Y, Sung-Sil, K & Kimura, M 1991, 'Conserved amino acid residues in ribosome-inactivating proteins from plants', Biochimie, vol. 73, no. 7-8, pp. 1157-1161. https://doi.org/10.1016/0300-9084(91)90160-3
Funatsu G, Islam MR, Minami Y, Sung-Sil K, Kimura M. Conserved amino acid residues in ribosome-inactivating proteins from plants. Biochimie. 1991 Jan 1;73(7-8):1157-1161. https://doi.org/10.1016/0300-9084(91)90160-3
Funatsu, G. ; Islam, MR ; Minami, Y. ; Sung-Sil, K. ; Kimura, Makoto. / Conserved amino acid residues in ribosome-inactivating proteins from plants. In: Biochimie. 1991 ; Vol. 73, No. 7-8. pp. 1157-1161.
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