Abstract
Background/Aims: The multiple occurrence of primary squamous cell carcinoma of the esophagus is often observed, and most such occurrences are double cancers. There have also been some cases with three or more intra-esophageal cancers, however, no detailed clinicopathologic study has yet been performed in the literature. Methodology: Two hundred and fifty patients of primary esophageal squamous cell carcinoma without preoperative treatment that underwent esophageal resection were re-evaluated by serial histopathologic investigations and we analyzed the data of ten patients with three or more intraesophageal cancers. Results: The clinical and histopathologic characteristics were as follows; 1) all but one of the cases were male, 2) all patients had a history of both heavy smoking and drinking but only one case had a family history of esophageal cancers among their siblings, 3) the depth of invasion in the carcinomas was restricted to within the submucosal layer of the esophageal wall, which was defined as superficial esophageal carcinoma, almost all (90%) of the cases accompanied esophageal squamous epithelial dysplasia. Conclusions: Based on these prominent characteristics of considerable multiple intra-esophageal cancers, a new clinical entity of "esophageal field cancers" could thus be suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 1713-1716 |
| Number of pages | 4 |
| Journal | Hepato-gastroenterology |
| Volume | 51 |
| Issue number | 60 |
| Publication status | Published - Nov 1 2004 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Gastroenterology
Cite this
Considerable multiple esophageal carcinoma. Implications of a new clinical entity. / Kuwano, Hiroyuki; Egashira, Akinori; Araki, Kohshi; Saeki, Hiroshi; Kawaguchi, Hidetoshi; Morita, Masaru; Kitamura, Kaoru; Sugimachi, Keizo.
In: Hepato-gastroenterology, Vol. 51, No. 60, 01.11.2004, p. 1713-1716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Considerable multiple esophageal carcinoma. Implications of a new clinical entity
AU - Kuwano, Hiroyuki
AU - Egashira, Akinori
AU - Araki, Kohshi
AU - Saeki, Hiroshi
AU - Kawaguchi, Hidetoshi
AU - Morita, Masaru
AU - Kitamura, Kaoru
AU - Sugimachi, Keizo
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Background/Aims: The multiple occurrence of primary squamous cell carcinoma of the esophagus is often observed, and most such occurrences are double cancers. There have also been some cases with three or more intra-esophageal cancers, however, no detailed clinicopathologic study has yet been performed in the literature. Methodology: Two hundred and fifty patients of primary esophageal squamous cell carcinoma without preoperative treatment that underwent esophageal resection were re-evaluated by serial histopathologic investigations and we analyzed the data of ten patients with three or more intraesophageal cancers. Results: The clinical and histopathologic characteristics were as follows; 1) all but one of the cases were male, 2) all patients had a history of both heavy smoking and drinking but only one case had a family history of esophageal cancers among their siblings, 3) the depth of invasion in the carcinomas was restricted to within the submucosal layer of the esophageal wall, which was defined as superficial esophageal carcinoma, almost all (90%) of the cases accompanied esophageal squamous epithelial dysplasia. Conclusions: Based on these prominent characteristics of considerable multiple intra-esophageal cancers, a new clinical entity of "esophageal field cancers" could thus be suggested.
AB - Background/Aims: The multiple occurrence of primary squamous cell carcinoma of the esophagus is often observed, and most such occurrences are double cancers. There have also been some cases with three or more intra-esophageal cancers, however, no detailed clinicopathologic study has yet been performed in the literature. Methodology: Two hundred and fifty patients of primary esophageal squamous cell carcinoma without preoperative treatment that underwent esophageal resection were re-evaluated by serial histopathologic investigations and we analyzed the data of ten patients with three or more intraesophageal cancers. Results: The clinical and histopathologic characteristics were as follows; 1) all but one of the cases were male, 2) all patients had a history of both heavy smoking and drinking but only one case had a family history of esophageal cancers among their siblings, 3) the depth of invasion in the carcinomas was restricted to within the submucosal layer of the esophageal wall, which was defined as superficial esophageal carcinoma, almost all (90%) of the cases accompanied esophageal squamous epithelial dysplasia. Conclusions: Based on these prominent characteristics of considerable multiple intra-esophageal cancers, a new clinical entity of "esophageal field cancers" could thus be suggested.
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M3 - Article
VL - 51
SP - 1713
EP - 1716
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 60
ER -