Consideration of the optimal epidural fentanyl doses in abdominal surgery

Masayuki Arakawa, Sumio Hoka

Research output: Contribution to journalArticle

Abstract

Study Objective: To determine an optimal dose of epidural fentanyl in open abdominal surgery by examining the effects of different doses of epidural fentanyl in combination with or without low concentration of lidocaine on hemodynamic and endocrine responses to surgical stress. Design: Prospective, randomized study. Setting: University hospital. Patients: 40 ASA physical status I and II patients scheduled for elective abdominal surgery including gastrectomy (n = 20), colectomy (n = 10), liver tumor resection (n = 2), pancreatectomy (n = 3), pancreaticoduodenectomy (n = 1), low anterior resection (n = 3), and cholecystectomy (n = 1). Interventions: Patients were randomly allocated to one of two groups: epidural fentanyl with 0.5% lidocaine (Group L + F; n = 25) or epidural fentanyl alone (Group F; n = 15). Both two groups were divided into subgroups; in Group L + F, epidural fentanyl was administered as doses of 0, 0.3, 1, 3, and 5 μg/kg in 5 patients each. In Group F, epidural fentanyl was administered as doses of 1, 3, and 5 μg/kg in 5 patients each. Hemodynamic data and plasma catecholamine concentrations were compared between before the epidural injection and immediately after peritoneal incision. Measurements and Main Results: There was no difference in mean arterial pressure (MAP) and heart rate (HR) between Group L + F and Group F at the time before epidural administration of fentanyl, 20 minutes after epidural fentanyl, and immediately after peritonal incision. However, there were significant decreases in MAP immediately after skin incision in epidural fentanyl 0 and 3 μg/kg in Group L + F patients and also in epidural fentanyl 1 and 3 μg/kg in Group F patients. HR significantly decreased in epidural fentanyl 5 μg/kg of Group L + Fat peritoneal incision (p < 0.05). Plasma epinephrine decreased significantly in fentanyl 3 and 5 μg/kg in Group L + F immediately after peritoneal incision (p < 0.05), whereas the increase in norepinephrine was significant in Group F (p < 0.01). Plasma dopamine significantly increased only in fentanyl 1 μg/kg in Group F (p < 0.05). Conclusion: Epidural fentanyl 3 μg/kg with 0.5 % lidocaine may be most adequate for laparotomy because these doses caused neither bradycardia nor increments of norepinephrine perioperatively.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalJournal of Clinical Anesthesia
Volume10
Issue number7
DOIs
Publication statusPublished - Nov 1 1998

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Fentanyl
Lidocaine
Norepinephrine
Arterial Pressure
Heart Rate
Hemodynamics
Epidural Injections
Pancreatectomy
Pancreaticoduodenectomy
Colectomy
Cholecystectomy
Gastrectomy
Bradycardia
Laparotomy
Epinephrine
Catecholamines
Dopamine

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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Consideration of the optimal epidural fentanyl doses in abdominal surgery. / Arakawa, Masayuki; Hoka, Sumio.

In: Journal of Clinical Anesthesia, Vol. 10, No. 7, 01.11.1998, p. 551-556.

Research output: Contribution to journalArticle

Arakawa, Masayuki ; Hoka, Sumio. / Consideration of the optimal epidural fentanyl doses in abdominal surgery. In: Journal of Clinical Anesthesia. 1998 ; Vol. 10, No. 7. pp. 551-556.
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abstract = "Study Objective: To determine an optimal dose of epidural fentanyl in open abdominal surgery by examining the effects of different doses of epidural fentanyl in combination with or without low concentration of lidocaine on hemodynamic and endocrine responses to surgical stress. Design: Prospective, randomized study. Setting: University hospital. Patients: 40 ASA physical status I and II patients scheduled for elective abdominal surgery including gastrectomy (n = 20), colectomy (n = 10), liver tumor resection (n = 2), pancreatectomy (n = 3), pancreaticoduodenectomy (n = 1), low anterior resection (n = 3), and cholecystectomy (n = 1). Interventions: Patients were randomly allocated to one of two groups: epidural fentanyl with 0.5{\%} lidocaine (Group L + F; n = 25) or epidural fentanyl alone (Group F; n = 15). Both two groups were divided into subgroups; in Group L + F, epidural fentanyl was administered as doses of 0, 0.3, 1, 3, and 5 μg/kg in 5 patients each. In Group F, epidural fentanyl was administered as doses of 1, 3, and 5 μg/kg in 5 patients each. Hemodynamic data and plasma catecholamine concentrations were compared between before the epidural injection and immediately after peritoneal incision. Measurements and Main Results: There was no difference in mean arterial pressure (MAP) and heart rate (HR) between Group L + F and Group F at the time before epidural administration of fentanyl, 20 minutes after epidural fentanyl, and immediately after peritonal incision. However, there were significant decreases in MAP immediately after skin incision in epidural fentanyl 0 and 3 μg/kg in Group L + F patients and also in epidural fentanyl 1 and 3 μg/kg in Group F patients. HR significantly decreased in epidural fentanyl 5 μg/kg of Group L + Fat peritoneal incision (p < 0.05). Plasma epinephrine decreased significantly in fentanyl 3 and 5 μg/kg in Group L + F immediately after peritoneal incision (p < 0.05), whereas the increase in norepinephrine was significant in Group F (p < 0.01). Plasma dopamine significantly increased only in fentanyl 1 μg/kg in Group F (p < 0.05). Conclusion: Epidural fentanyl 3 μg/kg with 0.5 {\%} lidocaine may be most adequate for laparotomy because these doses caused neither bradycardia nor increments of norepinephrine perioperatively.",
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