A glycosyl inositolphosphoceramide-type ganglioside, CJP4, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthus japonica. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 9-O-methyl-(N- glycolyl-α-D-neuraminosyl)-( 2→11)-9-O-methyl-(N-glycolyl-α-D- neuraminosyl)-(2→11)-9-O-methyl-(N-glycolyl-α-D-neuraminosyl) -(2→3)-inositolphosphoceramide, which contains C16-sphingosine and C22:0-, C24:0-fatty acid. This is the first report on the isolation and structural elucidation of a trisialo-glycosyl inositolphosphoceramide-type ganglioside. Moreover, CJP4 exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor.
All Science Journal Classification (ASJC) codes
- Drug Discovery