Constituents of crinoidea. 5. Isolation and structure of a new glycosyl inositolphosphoceramide-type ganglioside from the feather star Comanthina schlegeli

Masanori Inagaki, Masahide Shiizaki, Takashi Hiwatashi, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A new glycosyl inositolphosphoceramide-type ganglioside, CSP2, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthina schlegeli together with a known same type of ganglioside CJP2. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 9-O-methyl-(N-acetyl-α-D-neuraminosyl)- (2→3)-inositolphosphoceramide, which contains C16-sphingosine and C22:0-, C24:0-fatty acid as major component. This is the first report on the isolation and structural elucidation of a glycosyl inositolphosphoceramide-type ganglioside possessing N-acetyl-neuraminic acid (NeuAc) residue.

Original languageEnglish
Pages (from-to)1649-1651
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number11
DOIs
Publication statusPublished - Nov 2007

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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