Constituents of holothuroidea, 12. Isolation and structure of glucocerebrosides from the sea cucumber Holothuria pervicax

Koji Yamada, Kaori Sasaki, Yasuo Harada, Ryuichi Isobe, Ryuichi Higuchi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Ten glucocerebrosides, HPC-3-A-HPC-3-J, have been isolated from their obtained parent glucocerebroside molecular species HPC-3, together with other glucocerebroside molecular species HPC-1 and HPC-2, from the less polar lipid fraction of a chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these glucocerebrosides have been determined on the basis of chemical and spectroscopic evidence. Reversed-phase HPLC, including a recycling system, was effective in isolating these glucocerebrosides, revealing a very close resemblance in structure, though the problem due to regio-isomers remains.

Original languageEnglish
Pages (from-to)1467-1470
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume50
Issue number11
DOIs
Publication statusPublished - Nov 1 2002

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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