Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus

Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A ganglioside molecular species SJG-1 has been obtained from the n- hexane soluble lipid fraction of the chloroform/ methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N- glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.

Original languageEnglish
Pages (from-to)3171-3174
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number11
Publication statusPublished - Nov 1999

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phytosphingosine
Gangliosides
acids
Ceramides
N-Acetylneuraminic Acid
Nerve Growth Factor
fatty acids
Chloroform
chloroform
cultured cells
rats
Methanol
lipids
Rats
Fatty Acids
methyl alcohol
Cells
Lipids
cells
n-hexane

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus. / Kaneko, Masafumi; Kisa, Fumiaki; Yamada, Koji; Miyamoto, Tomofumi; Higuchi, Ryuichi.

In: European Journal of Organic Chemistry, No. 11, 11.1999, p. 3171-3174.

Research output: Contribution to journalArticle

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