Constituents of holothuroidea, 8([≠]). - Structure of neuritogenic active ganglioside from the sea cucumber Stichopus japonicus

Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A ganglioside molecular species SJG-1 has been obtained from the n- hexane soluble lipid fraction of the chloroform/ methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N- glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.

Original languageEnglish
Pages (from-to)3171-3174
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number11
DOIs
Publication statusPublished - Nov 1999

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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