Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata

Tomofumi Miyamoto, Kenichi Togawa, Ryuichi Higuchi, Tetsuya Komori, Takuma Sasaki

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Abstract

From the whole body of sea cucumber Cucumaria echinata (Cucumariidae), we recently identified six genuine holostane‐type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures 1–6 were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10, 11, and 12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investigated.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalLiebigs Annalen der Chemie
Volume1990
Issue number5
DOIs
Publication statusPublished - Jan 1 1990

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Cucumaria
Sea Cucumbers
KB Cells
Glycosides
Sulfates
Squamous Cell Carcinoma
Lymphoma
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata. / Miyamoto, Tomofumi; Togawa, Kenichi; Higuchi, Ryuichi; Komori, Tetsuya; Sasaki, Takuma.

In: Liebigs Annalen der Chemie, Vol. 1990, No. 5, 01.01.1990, p. 453-460.

Research output: Contribution to journalArticle

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