Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax

Koji Yamada, Yasuo Harada, Tomofumi Miyamoto, Ryuichi Isobi, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A new ganglioside molecular species, HPG-7 (1) was obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber, Holothuria pervicax. On the basis of chemical and spectroscopic evidence, the structure of I was determined, and the major component was 1-O-[α-L- fucopyranosyl-(1→4)-(N-acetyl-α-D-neuraminosyl)-(2→11)-(N-glycolyl-α-D- neuraminosyl)-(2→4)-(N-acetyl-α-D-neuraminosyl)-(2→6)-β-D- glucopyranosyl]-(2S,3S,4R)-2-[(2R)-2-hydroxytetracosanylamino]-14-methyl- hexadecane-1,3,4-triol. This is the first report on the isolation and structure elucidation of trisialo-ganglioside from sea cucumber. 1 showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell.

Original languageEnglish
Pages (from-to)157-159
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 2000

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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