Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors

Yoshihiro Baba, Karla P. Garrett, Paul W. Kincade

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

β-catenin-mediated Wnt signaling may contribute to the self-renewal of hematopoietic stem cells and proliferation in some malignancies. We now show that expression of constitutively active β-catenin in normal lymphoid or myeloid progenitors generated uncommitted cells with multilineage differentiation potential. Inappropriate gene expression occurred in cells destined to produce either cell type and caused corresponding changes in their characteristics. For example, forced activation of β-catenin quickly increased C/EBPα while reducing EBF and Pax-5 in lymphoid progenitors that then generated myeloid cells. Inversely, EBF dramatically increased in transduced myeloid progenitors and lymphocytes were produced. The results indicate that ectopic activation of β-catenin destabilizes lineage fate decisions and confers some, but not all, stem cell properties on committed progenitors.

Original languageEnglish
Pages (from-to)599-609
Number of pages11
JournalImmunity
Volume23
Issue number6
DOIs
Publication statusPublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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