Construction and Gilding of Metal-Organic Frameworks and Microtubule Conjugates

Masaki Ito, Takumi Ishiwata, Shizuka Anan, Kenta Kokado, Daisuke Inoue, Arif M.R. Kabir, Akira Kakugo, Kazuki Sada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Metal-organic frameworks (MOFs) are well-ordered microporous crystalline materials synthesized from metal cluster nodes and organic ligands. Using organic ligands with functional and reactive moieties enables post-synthetic modification (PSM) for further functionalization of MOFs. In this study, bioconjugation of MOFs with functional motor proteins, such as kinesin-microtubule (MT) system was investigated by employing PSM. Kinesin-MT system, energy diffusive gliding motion of MT was performed by consuming chemical energy of adenosine-tri-phosphate (ATP) in vitro. Thus, we attempted establishment of gliding of MOF by applying bio-motor system, in which reconstituted MT filaments are propelled over a kinesin-coated substrate in the presence of ATP.

Original languageEnglish
Pages (from-to)5358-5362
Number of pages5
JournalChemistrySelect
Volume1
Issue number16
DOIs
Publication statusPublished - Oct 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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