Construction of a blood-compatible interface based on surface segregation in a polymer blend

Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The technique of surface segregation was applied to prepare a bio-inert polymer interface. A small amount, 10 wt%, of poly(2-methoxyethyl acrylate) (PMEA), which exhibits excellent bio-inertness properties, fed into a matrix polymer was able to suppress platelet adhesion sufficiently to be of practical use. PMEA was effective because it was preferentially segregated at the outermost region of the polymer blend. Combining interfacial-sensitive analyses such as the air bubble contact angle and neutron reflectivity measurements and sum-frequency generation spectroscopy with the platelet adhesion test gives a better understanding of how the bio-inert property is expressed at the water interface.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
Journalpolymer
Volume78
DOIs
Publication statusPublished - Nov 5 2015

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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