Construction of a new type of chiral bidentate NHC ligands: copper-catalyzed asymmetric conjugate alkylation

Tatsuya Uchida, Tsutomu Katsuki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We synthesized in three steps simple chiral bidentate NHC compounds that carry an achiral coordinating group as N-substituent and revealed that they serve as efficient chiral auxiliaries for the copper-catalyzed asymmetric conjugate addition of dialkylzinc to acyclic enones (up to 97% ee).

Original languageEnglish
Pages (from-to)4741-4743
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number33
DOIs
Publication statusPublished - Aug 18 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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