Construction of cardiac tissue rings using a magnetic tissue fabrication technique

Hirokazu Akiyama, Akira Ito, Masanori Sato, Yoshinori Kawabe, Masamichi Kamihira

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Here we applied a magnetic force-based tissue engineering technique to cardiac tissue fabrication. A mixture of extracellular matrix precursor and cardiomyocytes labeled with magnetic nanoparticles was added into a well containing a central polycarbonate cylinder. With the use of a magnet, the cells were attracted to the bottom of the well and allowed to form a cell layer. During cultivation, the cell layer shrank towards the cylinder, leading to the formation of a ring-shaped tissue that possessed a multilayered cell structure and contractile properties. These results indicate that magnetic tissue fabrication is a promising approach for cardiac tissue engineering.

Original languageEnglish
Pages (from-to)2910-2920
Number of pages11
JournalInternational journal of molecular sciences
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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