Abstract
The diastereo- and enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand (1) was examined. Michael adducts (4) were obtained in excellent chemical yields (95~99%) with high stereoselectivities (syn-4/anti-4: 16/84~1/99; ee of anti-4: 81~99%) by the reaction between alkyl phenyl ketones (2) and Michael accepters (3) having an alkylidene group.
Original language | English |
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Pages (from-to) | 3531-3534 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 38 |
Issue number | 20 |
DOIs | |
Publication status | Published - May 19 1997 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry