The diastereo- and enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand (1) was examined. Michael adducts (4) were obtained in excellent chemical yields (95~99%) with high stereoselectivities (syn-4/anti-4: 16/84~1/99; ee of anti-4: 81~99%) by the reaction between alkyl phenyl ketones (2) and Michael accepters (3) having an alkylidene group.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry