Construction of contiguous chiral tertiary carbon centers by enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand

Kosuke Yasuda, Mitsum Shindo, Kenji Koga

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18 Citations (Scopus)

Abstract

The diastereo- and enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand (1) was examined. Michael adducts (4) were obtained in excellent chemical yields (95~99%) with high stereoselectivities (syn-4/anti-4: 16/84~1/99; ee of anti-4: 81~99%) by the reaction between alkyl phenyl ketones (2) and Michael accepters (3) having an alkylidene group.

Original languageEnglish
Pages (from-to)3531-3534
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number20
DOIs
Publication statusPublished - May 19 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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