Construction of dye-stapled Quenchbodies by photochemical crosslinking to antibody nucleotide-binding sites

Hee Jin Jeong, Kenji Matsumoto, Shuya Itayama, Kozue Kodama, Ryoji Abe, Jinhua Dong, Mitsuru Shindo, Hiroshi Ueda

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We successfully converted an antibody single-chain variable fragment and a full-sized antibody to Quenchbodies, which are a type of powerful fluorescent immunosensor, through ultraviolet-based photochemical crosslinking of an indole-3-butyric acid-conjugated fluorescent dye to the nucleotide-binding sites near the antigen-binding sites.

Original languageEnglish
Pages (from-to)10200-10203
Number of pages4
JournalChemical Communications
Volume53
Issue number73
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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