Construction of nano-structures by self-assembly of C3-symmetric peptide conjugates

Kazunori Matsuura, Hironori Matsuyama, Kazuya Murasato, Nobuo Kimizuka

    Research output: Contribution to conferencePaperpeer-review

    1 Citation (Scopus)

    Abstract

    Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject in biotechnology and also in bottom-up nanotechnology. To mimick formation of spherical viruses and clathrin, we have reported design of a C3-symmetric peptide conjugate bearing three β-sheet forming peptides (Trigonal-FKFE) and their self-assembly into nanospheres in acidic solutions. Here we report a novel C3-symmetric peptide conjugate (Wheel-FKFE) which have wheel-like arrangement. The Wheel-FKFE self-assembled into nanofibers with uniform width (3 nm) in neutral aqueous solutions. Furthermore, we developed a simpler trigonal conjugate bearing glutathione as self-assembly units (Trigonal-glutathione). The conjugate self-assembled into nanocapsules with the size of about 300 nm in aqueous solutions.

    Original languageEnglish
    Pages5217-5218
    Number of pages2
    Publication statusPublished - Dec 1 2006
    Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
    Duration: Sep 20 2006Sep 22 2006

    Other

    Other55th Society of Polymer Science Japan Symposium on Macromolecules
    Country/TerritoryJapan
    CityToyama
    Period9/20/069/22/06

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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