Construction of nano-structures by self-assembly of C3-symmetric peptide conjugates

Kazunori Matsuura, Hironori Matsuyama, Kazuya Murasato, Nobuo Kimizuka

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)


Rational design of self-assembly of proteins, which plays pivotal roles in biology, is an important subject in biotechnology and also in bottom-up nanotechnology. To mimick formation of spherical viruses and clathrin, we have reported design of a C3-symmetric peptide conjugate bearing three β-sheet forming peptides (Trigonal-FKFE) and their self-assembly into nanospheres in acidic solutions. Here we report a novel C3-symmetric peptide conjugate (Wheel-FKFE) which have wheel-like arrangement. The Wheel-FKFE self-assembled into nanofibers with uniform width (3 nm) in neutral aqueous solutions. Furthermore, we developed a simpler trigonal conjugate bearing glutathione as self-assembly units (Trigonal-glutathione). The conjugate self-assembled into nanocapsules with the size of about 300 nm in aqueous solutions.

Original languageEnglish
Number of pages2
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006


Other55th Society of Polymer Science Japan Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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