Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4

Norihiko Yokoi, Hiroshi Inaba, Makoto Terauchi, Adam Z. Stieg, Nusrat J.M. Sanghamitra, Tomomi Koshiyama, Katsuhide Yutani, Shuji Kanamaru, Fumio Arisaka, Tatsuo Hikage, Atsuo Suzuki, Takashi Yamane, James K. Gimzewski, Yoshihito Watanabe, Susumu Kitagawa, Takafumi Ueno

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Achieving control over the structures of artifi cial protein and peptide assemblies is a worthwhile goal because it would provide a powerful approach for the construction of nanomaterials.[1-4] Artifi cial self-assembled proteins obtained using protein engineering techniques could then be obtained by designing quaternary structures that include modifi ed protein-protein interfaces,[5-9] fusion proteins,[10-13] chemical conjugations,[14,15] and self-assembly of short peptides. [16,17] The resulting protein assembly structures in the form of tubes,[6,10] cages,[5,7,9,11] rings [18] and 2D layers [12,14,15] could serve as nanoreactors and nanotemplates. In particular, tube structures offer great promise as building blocks of nanomaterials designed for applications such as molecular sensing, drug delivery, imaging, catalysis, and the synthesis of new materials. [2,4,10,13,19-23] Although several studies showed that tubular protein assemblies have been adopted as protein-based platforms for catalytic reactions promoted by enzymes or fl uorescent molecules displayed on the surfaces,[2,4,10,13,19-23] it is diffi cult to control the reactivity of these systems by fixation of functional molecules at appropriate sites. Thus, it has remained challenging to obtain tube structures with high stability and well-defi ned nanoscale lengths for properly aligning synthetic molecules on the surfaces of the nanotubes.

Original languageEnglish
Pages (from-to)1873-1879
Number of pages7
JournalSmall
Volume6
Issue number17
DOIs
Publication statusPublished - Sep 6 2010

Fingerprint

Nanotubes
Bacteriophage T4
Bacteriophages
Self assembly
Proteins
Nanostructures
Nanostructured materials
Peptides
Molecules
Protein Engineering
Nanoreactors
Catalysis
Drug delivery
Fusion reactions
Enzymes
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Yokoi, N., Inaba, H., Terauchi, M., Stieg, A. Z., Sanghamitra, N. J. M., Koshiyama, T., ... Ueno, T. (2010). Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4. Small, 6(17), 1873-1879. https://doi.org/10.1002/smll.201000772

Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4. / Yokoi, Norihiko; Inaba, Hiroshi; Terauchi, Makoto; Stieg, Adam Z.; Sanghamitra, Nusrat J.M.; Koshiyama, Tomomi; Yutani, Katsuhide; Kanamaru, Shuji; Arisaka, Fumio; Hikage, Tatsuo; Suzuki, Atsuo; Yamane, Takashi; Gimzewski, James K.; Watanabe, Yoshihito; Kitagawa, Susumu; Ueno, Takafumi.

In: Small, Vol. 6, No. 17, 06.09.2010, p. 1873-1879.

Research output: Contribution to journalArticle

Yokoi, N, Inaba, H, Terauchi, M, Stieg, AZ, Sanghamitra, NJM, Koshiyama, T, Yutani, K, Kanamaru, S, Arisaka, F, Hikage, T, Suzuki, A, Yamane, T, Gimzewski, JK, Watanabe, Y, Kitagawa, S & Ueno, T 2010, 'Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4', Small, vol. 6, no. 17, pp. 1873-1879. https://doi.org/10.1002/smll.201000772
Yokoi N, Inaba H, Terauchi M, Stieg AZ, Sanghamitra NJM, Koshiyama T et al. Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4. Small. 2010 Sep 6;6(17):1873-1879. https://doi.org/10.1002/smll.201000772
Yokoi, Norihiko ; Inaba, Hiroshi ; Terauchi, Makoto ; Stieg, Adam Z. ; Sanghamitra, Nusrat J.M. ; Koshiyama, Tomomi ; Yutani, Katsuhide ; Kanamaru, Shuji ; Arisaka, Fumio ; Hikage, Tatsuo ; Suzuki, Atsuo ; Yamane, Takashi ; Gimzewski, James K. ; Watanabe, Yoshihito ; Kitagawa, Susumu ; Ueno, Takafumi. / Construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage T4. In: Small. 2010 ; Vol. 6, No. 17. pp. 1873-1879.
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